2-bromo-6-(5-methoxy-1-methyl-1H-indol-3-yl)-5H-pyrrolo[2,3-b]pyrazine

InChIKey	`ZBYGBITZFKOQTA-UHFFFAOYSA-N`
Compound Name	2-bromo-6-(5-methoxy-1-methyl-1H-indol-3-yl)-5H-pyrrolo[2,3-b]pyrazine
Canonical SMILES	`COc1ccc2c(c1)c(-c1cc3nc(Br)cnc3[nH]1)cn2C`
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	18
Pfam Stratification	Cross-Family
Avg pChEMBL	6.53
Source	ChEMBL

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
P50613	CDK7	Homo sapiens	Human	PF00069	7.5	Ki	ChEMBL
O14965	AURKA	Homo sapiens	Human	PF00069	7.3	Ki	ChEMBL
P36888	FLT3	Homo sapiens	Human	PF00047 PF07714	7.1	Ki	ChEMBL
Q16620	NTRK2	Homo sapiens	Human	PF07679 PF13855 PF16920 PF01462 PF07714	7.0	Ki	ChEMBL
P00519	ABL1	Homo sapiens	Human	PF08919 PF07714 PF00017 PF00018	6.7	Ki	ChEMBL
Q9HAZ1	CLK4	Homo sapiens	Human	PF00069	6.7	Ki	ChEMBL
P06241	FYN	Homo sapiens	Human	PF07714 PF00017 PF00018	6.4	Ki	ChEMBL
P07949	RET	Homo sapiens	Human	PF00028 PF07714 PF17756 PF17812 PF17813 PF22540	6.4	Ki	ChEMBL
P49841	GSK3B	Homo sapiens	Human	PF00069	6.4	Ki	ChEMBL
Q02750	MAP2K1	Homo sapiens	Human	PF00069	6.4	Ki	ChEMBL
P04629	NTRK1	Homo sapiens	Human	PF13855 PF16920 PF07714 PF18613	6.3	Ki	ChEMBL
P08069	IGF1R	Homo sapiens	Human	PF00757 PF07714 PF01030	6.3	Ki	ChEMBL
P49840	GSK3A	Homo sapiens	Human	PF00069	6.3	Ki	ChEMBL
P45983	MAPK8	Homo sapiens	Human	PF00069	6.2	Ki	ChEMBL
Q16288	NTRK3	Homo sapiens	Human	PF07679 PF00047 PF13855 PF16920 PF01462 PF07714	6.2	Ki	ChEMBL
Q96GD4	AURKB	Homo sapiens	Human	PF00069	6.2	Ki	ChEMBL
P11362	FGFR1	Homo sapiens	Human	PF07679 PF00047 PF07714	6.1	Ki	ChEMBL
Q5S007	LRRK2	Homo sapiens	Human	PF23745 PF23744 PF23748 PF16095 PF25497 PF13855 PF00069 PF08477	6.0	Ki	ChEMBL