Molecule Details
| InChIKey | ZABQHWUKKILDGH-UHFFFAOYSA-N |
|---|---|
| Compound Name | 6-[(4-acetyl-2-ethyl-5-hydroxyphenoxy)methyl]-N-[4-[2-(hydroxyamino)-2-oxoethyl]-1,3-thiazol-2-yl]pyridine-2-carboxamide |
| Canonical SMILES | CCc1cc(C(C)=O)c(O)cc1OCc1cccc(C(=O)Nc2nc(CC(=O)NO)cs2)n1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 7.19 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| O76074 | PDE5A | Homo sapiens | Human | PF01590 PF00233 | 7.6 | IC50 | ChEMBL;BindingDB |
| P54750 | PDE1A | Homo sapiens | Human | PF00233 PF08499 | 7.1 | IC50 | ChEMBL |
| Q01064 | PDE1B | Homo sapiens | Human | PF00233 PF08499 | 7.1 | IC50 | ChEMBL;BindingDB |
| Q14123 | PDE1C | Homo sapiens | Human | PF00233 PF08499 | 7.1 | IC50 | ChEMBL |