Molecule Details
InChIKeyYYLKKYCXAOBSRM-JXMROGBWSA-N
Compound NameKw-2449
Canonical SMILESO=C(c1ccc(/C=C/c2n[nH]c3ccccc23)cc1)N1CCNCC1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)191
Pfam Stratification Cross-Family
Avg pChEMBL6.72
SourceBindingDB;ChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (191)
Target Gene Organism Category Pfam pChEMBL Type Source
Q9UEE5 STK17A Homo sapiens Human PF00069 8.5 Kd ChEMBL;BindingDB
Q9NTK5 OLA1 Homo sapiens Human PF01926 PF06071 8.5 Kd ChEMBL
Q13177 PAK2 Homo sapiens Human PF00786 PF00069 8.4 Kd ChEMBL
Q32MK0 MYLK3 Homo sapiens Human PF00069 8.4 Kd ChEMBL;BindingDB
O94768 STK17B Homo sapiens Human PF00069 8.3 Kd ChEMBL;BindingDB
Q56UN5 MAP3K19 Homo sapiens Human PF00069 8.3 Kd ChEMBL;BindingDB
Q9NSY1 BMP2K Homo sapiens Human PF15282 PF00069 8.0 Kd ChEMBL;BindingDB
Q12851 MAP4K2 Homo sapiens Human PF00780 PF00069 8.0 Kd ChEMBL;BindingDB
O94804 STK10 Homo sapiens Human PF00069 PF12474 7.9 Kd ChEMBL;BindingDB
Q9H2G2 SLK Homo sapiens Human PF00069 PF12474 7.9 Kd ChEMBL;BindingDB
P36888 FLT3 Homo sapiens Human PF00047 PF07714 7.9 Kd ChEMBL;BindingDB
P78362 SRPK2 Homo sapiens Human PF00069 7.8 Kd ChEMBL;BindingDB
P07947 YES1 Homo sapiens Human PF07714 PF00017 PF00018 7.7 Kd ChEMBL;BindingDB
O00444 PLK4 Homo sapiens Human PF00069 PF18190 PF18409 7.7 Kd ChEMBL;BindingDB
Q8N4C8 MINK1 Homo sapiens Human PF00780 PF00069 7.6 Kd ChEMBL;BindingDB
Q9UKE5 TNIK Homo sapiens Human PF00780 PF00069 7.5 Kd ChEMBL;BindingDB
O75716 STK16 Homo sapiens Human PF00069 7.5 Kd ChEMBL;BindingDB
P00519 ABL1 Homo sapiens Human PF08919 PF07714 PF00017 PF00018 7.5 Kd ChEMBL;BindingDB
P09619 PDGFRB Homo sapiens Human PF00047 PF13927 PF25305 PF07714 7.5 Kd ChEMBL;BindingDB
O95819 MAP4K4 Homo sapiens Human PF00780 PF00069 7.5 Kd ChEMBL;BindingDB
O43318 MAP3K7 Homo sapiens Human PF07714 7.4 Kd ChEMBL;BindingDB
P52333 JAK3 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 7.4 Kd ChEMBL;BindingDB
P07949 RET Homo sapiens Human PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 7.3 Kd ChEMBL;BindingDB
Q9BRS2 RIOK1 Homo sapiens Human PF01163 7.3 Kd ChEMBL;BindingDB
P51617 IRAK1 Homo sapiens Human PF00531 PF00069 7.3 Kd ChEMBL;BindingDB
Q2M2I8 AAK1 Homo sapiens Human PF00069 7.3 Kd ChEMBL;BindingDB
Q9HAZ1 CLK4 Homo sapiens Human PF00069 7.3 Kd ChEMBL;BindingDB
P53779 MAPK10 Homo sapiens Human PF00069 7.3 Kd ChEMBL;BindingDB
Q99755 PIP5K1A Homo sapiens Human PF01504 7.3 Kd ChEMBL;BindingDB
O75385 ULK1 Homo sapiens Human PF12063 PF21127 PF00069 7.3 Kd ChEMBL;BindingDB
Q9H1R3 MYLK2 Homo sapiens Human PF00069 7.3 Kd ChEMBL;BindingDB
Q9H093 NUAK2 Homo sapiens Human PF00069 7.3 Kd ChEMBL;BindingDB
Q96SB4 SRPK1 Homo sapiens Human PF00069 7.3 Kd ChEMBL;BindingDB
Q9UQB9 AURKC Homo sapiens Human PF00069 7.2 Kd ChEMBL;BindingDB
O14730 RIOK3 Homo sapiens Human PF01163 7.2 Kd ChEMBL;BindingDB
P10721 KIT Homo sapiens Human PF00047 PF07714 7.2 Kd ChEMBL;BindingDB
Q92918 MAP4K1 Homo sapiens Human PF00780 PF00069 7.2 Kd ChEMBL;BindingDB
P49759 CLK1 Homo sapiens Human PF00069 7.2 Kd ChEMBL;BindingDB
Q13546 RIPK1 Homo sapiens Human PF00531 PF07714 7.2 Kd ChEMBL;BindingDB
P80370 DLK1 Homo sapiens Human PF00008 7.2 Kd ChEMBL
Q12852 MAP3K12 Homo sapiens Human PF07714 7.2 Kd ChEMBL;BindingDB
P32298 GRK4 Homo sapiens Human PF00069 PF00615 7.2 Kd ChEMBL;BindingDB
P17948 FLT1 Homo sapiens Human PF07679 PF00047 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 7.1 Kd ChEMBL;BindingDB
Q9Y2U5 MAP3K2 Homo sapiens Human PF00564 PF00069 7.1 Kd ChEMBL;BindingDB
O60674 JAK2 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 7.1 Kd ChEMBL;BindingDB
Q8NFD2 ANKK1 Homo sapiens Human PF00023 PF12796 PF13637 PF07714 7.1 Kd ChEMBL;BindingDB
Q9C098 DCLK3 Homo sapiens Human PF00069 7.1 Kd ChEMBL;BindingDB
Q96GD4 AURKB Homo sapiens Human PF00069 7.1 Kd ChEMBL;BindingDB
P49760 CLK2 Homo sapiens Human PF00069 7.0 Kd ChEMBL;BindingDB
P78356 PIP4K2B Homo sapiens Human PF01504 7.0 Kd ChEMBL;BindingDB
O96017 CHEK2 Homo sapiens Human PF00498 PF00069 7.0 Kd ChEMBL;BindingDB
Q96BR1 SGK3 Homo sapiens Human PF00069 PF00433 PF00787 7.0 Kd ChEMBL;BindingDB
P33981 TTK Homo sapiens Human PF00069 7.0 Kd ChEMBL;BindingDB
O00238 BMPR1B Homo sapiens Human PF01064 PF07714 PF08515 6.9 Kd ChEMBL;BindingDB
P07333 CSF1R Homo sapiens Human PF00047 PF25305 PF07714 6.9 Kd ChEMBL;BindingDB
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 6.9 Kd ChEMBL;BindingDB
Q13163 MAP2K5 Homo sapiens Human PF00564 PF00069 6.9 Kd ChEMBL;BindingDB
Q6PHR2 ULK3 Homo sapiens Human PF04212 PF00069 6.9 Kd ChEMBL;BindingDB
Q99759 MAP3K3 Homo sapiens Human PF00564 PF00069 6.9 Kd ChEMBL;BindingDB
Q9HC98 NEK6 Homo sapiens Human PF00069 6.9 Kd ChEMBL;BindingDB
Q5S007 LRRK2 Homo sapiens Human PF23745 PF23744 PF23748 PF16095 PF25497 PF13855 PF00069 PF08477 6.9 Kd ChEMBL;BindingDB
O15197 EPHB6 Homo sapiens Human PF14575 PF25599 PF01404 PF07699 PF00041 PF07714 PF07647 6.9 Kd ChEMBL;BindingDB
P16234 PDGFRA Homo sapiens Human PF07679 PF25305 PF07714 6.9 Kd ChEMBL;BindingDB
P57078 RIPK4 Homo sapiens Human PF12796 PF13637 PF00069 6.9 Kd ChEMBL;BindingDB
Q8IYT8 ULK2 Homo sapiens Human PF12063 PF21127 PF00069 6.9 Kd ChEMBL;BindingDB
Q9UHD2 TBK1 Homo sapiens Human PF00069 PF18394 PF18396 6.9 Kd ChEMBL;BindingDB
P15735 PHKG2 Homo sapiens Human PF00069 6.8 Kd ChEMBL;BindingDB
Q04771 ACVR1 Homo sapiens Human PF01064 PF07714 PF08515 6.8 Kd ChEMBL;BindingDB
Q16620 NTRK2 Homo sapiens Human PF07679 PF13855 PF16920 PF01462 PF07714 6.8 Kd ChEMBL;BindingDB
Q9BYT3 STK33 Homo sapiens Human PF00069 6.8 Kd ChEMBL;BindingDB
P21709 EPHA1 Homo sapiens Human PF14575 PF25599 PF01404 PF07699 PF00041 PF07714 PF00536 6.8 Kd ChEMBL;BindingDB
P46734 MAP2K3 Homo sapiens Human PF00069 6.8 Kd ChEMBL;BindingDB
Q8IVH8 MAP4K3 Homo sapiens Human PF00780 PF00069 6.8 Kd ChEMBL;BindingDB
Q86YV6 MYLK4 Homo sapiens Human PF00069 6.8 Kd ChEMBL;BindingDB
O15111 CHUK Homo sapiens Human PF18397 PF12179 PF00069 6.7 Kd ChEMBL;BindingDB
P30530 AXL Homo sapiens Human PF00041 PF13927 PF07714 6.7 Kd ChEMBL;BindingDB
Q13627 DYRK1A Homo sapiens Human PF00069 6.7 Kd ChEMBL;BindingDB
P23458 JAK1 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 6.7 Kd ChEMBL;BindingDB
P50613 CDK7 Homo sapiens Human PF00069 6.7 Kd ChEMBL;BindingDB
O15146 MUSK Homo sapiens Human PF01392 PF07679 PF13927 PF07714 6.7 Kd ChEMBL;BindingDB
Q9UPE1 SRPK3 Homo sapiens Human PF00069 6.7 Kd ChEMBL;BindingDB
P08581 MET Homo sapiens Human PF07714 PF01437 PF01403 PF01833 6.7 Kd ChEMBL;BindingDB
Q14680 MELK Homo sapiens Human PF02149 PF00069 PF21594 6.7 Kd ChEMBL;BindingDB
Q16816 PHKG1 Homo sapiens Human PF00069 6.7 Kd ChEMBL;BindingDB
Q8N5S9 CAMKK1 Homo sapiens Human PF00069 6.7 Kd ChEMBL;BindingDB
Q8TDX7 NEK7 Homo sapiens Human PF00069 6.7 Kd ChEMBL;BindingDB
Q96L34 MARK4 Homo sapiens Human PF02149 PF00069 PF00627 6.7 Kd ChEMBL;BindingDB
P0C264 SBK3 Homo sapiens Human PF00069 6.6 Kd ChEMBL;BindingDB
P19784 CSNK2A2 Homo sapiens Human PF00069 6.6 Kd ChEMBL;BindingDB
P45984 MAPK9 Homo sapiens Human PF00069 6.6 Kd ChEMBL;BindingDB
Q16584 MAP3K11 Homo sapiens Human PF07714 PF14604 6.6 Kd ChEMBL;BindingDB
Q08881 ITK Homo sapiens Human PF00779 PF00169 PF07714 PF00017 PF00018 6.6 Kd ChEMBL;BindingDB
Q15831 STK11 Homo sapiens Human PF00069 6.6 Kd ChEMBL;BindingDB
Q9Y616 IRAK3 Homo sapiens Human PF00531 PF00069 6.6 Kd ChEMBL;BindingDB
O75116 ROCK2 Homo sapiens Human PF25346 PF00069 PF08912 6.6 Kd ChEMBL;BindingDB
P42684 ABL2 Homo sapiens Human PF08919 PF07714 PF00017 PF00018 6.6 Kd ChEMBL;BindingDB
P45985 MAP2K4 Homo sapiens Human PF00069 6.6 Kd ChEMBL;BindingDB
Q16288 NTRK3 Homo sapiens Human PF07679 PF00047 PF13855 PF16920 PF01462 PF07714 6.6 Kd ChEMBL;BindingDB
O14976 GAK Homo sapiens Human PF00069 PF10409 6.6 Kd ChEMBL;BindingDB
Q9Y4K4 MAP4K5 Homo sapiens Human PF00780 PF00069 6.6 Kd ChEMBL;BindingDB
P04629 NTRK1 Homo sapiens Human PF13855 PF16920 PF07714 PF18613 6.6 Kd ChEMBL;BindingDB
Q13523 PRP4K Homo sapiens Human PF00069 6.6 Kd ChEMBL;BindingDB
P22607 FGFR3 Homo sapiens Human PF21165 PF07679 PF13927 PF07714 6.5 Kd ChEMBL;BindingDB
P51812 RPS6KA3 Homo sapiens Human PF00069 PF00433 6.5 Kd ChEMBL;BindingDB
P29597 TYK2 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 6.5 Kd ChEMBL;BindingDB
Q6ZSR9 Homo sapiens Human PF15282 6.5 Kd ChEMBL
P35590 TIE1 Homo sapiens Human PF00041 PF00047 PF07714 6.5 Kd ChEMBL;BindingDB
Q13464 ROCK1 Homo sapiens Human PF25346 PF00069 PF08912 6.5 Kd ChEMBL;BindingDB
Q9H2X6 HIPK2 Homo sapiens Human PF00069 6.5 Kd ChEMBL;BindingDB
O43293 DAPK3 Homo sapiens Human PF00069 6.5 Kd ChEMBL;BindingDB
P23443 RPS6KB1 Homo sapiens Human PF00069 PF00433 6.5 Kd ChEMBL;BindingDB
Q9P0L2 MARK1 Homo sapiens Human PF02149 PF00069 PF00627 6.5 Kd ChEMBL;BindingDB
P27037 ACVR2A Homo sapiens Human PF01064 PF00069 6.5 Kd ChEMBL;BindingDB
Q9P2K8 EIF2AK4 Homo sapiens Human PF12745 PF00069 PF05773 PF13393 6.5 Kd ChEMBL;BindingDB
Q14164 IKBKE Homo sapiens Human PF00069 PF18394 PF18396 6.5 Kd ChEMBL;BindingDB
P53355 DAPK1 Homo sapiens Human PF00023 PF12796 PF13637 PF00531 PF00069 6.4 Kd ChEMBL;BindingDB
P11362 FGFR1 Homo sapiens Human PF07679 PF00047 PF07714 6.4 Kd ChEMBL;BindingDB
Q13705 ACVR2B Homo sapiens Human PF01064 PF00069 6.4 Kd ChEMBL;BindingDB
Q13873 BMPR2 Homo sapiens Human PF01064 PF00069 6.4 Kd ChEMBL;BindingDB
Q15208 STK38 Homo sapiens Human PF00069 PF00433 6.4 Kd ChEMBL;BindingDB
Q15375 EPHA7 Homo sapiens Human PF14575 PF25599 PF01404 PF07699 PF00041 PF07714 PF00536 6.4 Kd ChEMBL
Q92630 DYRK2 Homo sapiens Human PF00069 6.4 Kd ChEMBL;BindingDB
Q9P286 PAK5 Homo sapiens Human PF00786 PF00069 6.4 Kd ChEMBL;BindingDB
Q9UF33 EPHA6 Homo sapiens Human PF14575 PF25599 PF01404 PF07699 PF00041 PF07714 PF00536 6.4 Kd BindingDB
P06213 INSR Homo sapiens Human PF00757 PF17870 PF07714 PF01030 6.4 Kd ChEMBL;BindingDB
P14616 INSRR Homo sapiens Human PF00041 PF00757 PF07714 PF01030 6.4 Kd ChEMBL;BindingDB
O14920 IKBKB Homo sapiens Human PF18397 PF12179 PF00069 6.4 Kd ChEMBL;BindingDB
Q13131 PRKAA1 Homo sapiens Human PF16579 PF21147 PF00069 6.4 Kd ChEMBL;BindingDB
Q86Z02 HIPK1 Homo sapiens Human PF00069 6.4 Kd ChEMBL;BindingDB
P09769 FGR Homo sapiens Human PF07714 PF00017 PF00018 6.4 Kd ChEMBL;BindingDB
P54646 PRKAA2 Homo sapiens Human PF16579 PF21147 PF00069 6.4 Kd ChEMBL;BindingDB
Q7KZI7 MARK2 Homo sapiens Human PF02149 PF00069 PF00627 6.4 Kd ChEMBL;BindingDB
Q9UK32 RPS6KA6 Homo sapiens Human PF00069 PF00433 6.4 Kd ChEMBL;BindingDB
O75914 PAK3 Homo sapiens Human PF00786 PF00069 6.3 Kd ChEMBL;BindingDB
P57058 HUNK Homo sapiens Human PF00069 6.3 Kd ChEMBL;BindingDB
Q96RR4 CAMKK2 Homo sapiens Human PF00069 6.3 Kd ChEMBL;BindingDB
O43283 MAP3K13 Homo sapiens Human PF07714 6.3 Kd ChEMBL;BindingDB
Q02750 MAP2K1 Homo sapiens Human PF00069 6.3 Kd ChEMBL;BindingDB
Q8IU85 CAMK1D Homo sapiens Human PF00069 6.3 Kd ChEMBL;BindingDB
Q8TD19 NEK9 Homo sapiens Human PF00069 PF25390 6.3 Kd ChEMBL;BindingDB
O14965 AURKA Homo sapiens Human PF00069 6.3 Kd ChEMBL;BindingDB
Q13043 STK4 Homo sapiens Human PF11629 PF00069 6.2 Kd ChEMBL;BindingDB
Q9H0K1 SIK2 Homo sapiens Human PF00069 PF23312 6.2 Kd ChEMBL;BindingDB
P42681 TXK Homo sapiens Human PF07714 PF00017 PF00018 6.2 Kd ChEMBL;BindingDB
P45983 MAPK8 Homo sapiens Human PF00069 6.2 Kd ChEMBL;BindingDB
P78368 CSNK1G2 Homo sapiens Human PF12605 PF00069 6.2 Kd ChEMBL;BindingDB
Q13470 TNK1 Homo sapiens Human PF07714 PF22931 6.2 Kd ChEMBL;BindingDB
Q16512 PKN1 Homo sapiens Human PF02185 PF00069 PF00433 6.2 Kd ChEMBL;BindingDB
Q52WX2 SBK1 Homo sapiens Human PF00069 6.2 Kd ChEMBL;BindingDB
Q9H422 HIPK3 Homo sapiens Human PF00069 6.2 Kd ChEMBL;BindingDB
Q9NYL2 MAP3K20 Homo sapiens Human PF07714 PF07647 6.2 Kd ChEMBL;BindingDB
P00533 EGFR Homo sapiens Human PF00757 PF14843 PF07714 PF01030 PF21314 6.2 Kd ChEMBL;BindingDB
Q15349 RPS6KA2 Homo sapiens Human PF00069 PF00433 6.2 Kd ChEMBL;BindingDB
P49674 CSNK1E Homo sapiens Human PF00069 6.2 Kd ChEMBL;BindingDB
Q8TDR2 STK35 Homo sapiens Human PF00069 6.2 Kd ChEMBL;BindingDB
O14578 CIT Homo sapiens Human PF00780 PF00169 PF00069 PF00433 6.2 Kd ChEMBL;BindingDB
O15530 PDPK1 Homo sapiens Human PF14593 PF00069 6.2 Kd ChEMBL;BindingDB
P80192 MAP3K9 Homo sapiens Human PF07714 PF14604 6.2 Kd ChEMBL;BindingDB
P06241 FYN Homo sapiens Human PF07714 PF00017 PF00018 6.2 Kd ChEMBL;BindingDB
Q6XUX3 DSTYK Homo sapiens Human PF00069 6.2 Kd ChEMBL;BindingDB
Q9UM73 ALK Homo sapiens Human PF12810 PF00629 PF07714 6.2 Kd ChEMBL;BindingDB
P43405 SYK Homo sapiens Human PF07714 PF00017 6.2 Kd ChEMBL;BindingDB
P57059 SIK1 Homo sapiens Human PF00069 PF23312 6.2 Kd ChEMBL;BindingDB
Q9NWZ3 IRAK4 Homo sapiens Human PF07714 6.2 Kd ChEMBL;BindingDB
O14757 CHEK1 Homo sapiens Human PF00069 6.2 Kd ChEMBL;BindingDB
Q15746 MYLK Homo sapiens Human PF16620 PF00041 PF07679 PF00069 6.1 Kd ChEMBL;BindingDB
Q8NEV4 MYO3A Homo sapiens Human PF00612 PF00063 PF00069 6.1 Kd ChEMBL;BindingDB
P07332 FES Homo sapiens Human PF00611 PF07714 PF00017 6.1 Kd ChEMBL;BindingDB
P11802 CDK4 Homo sapiens Human PF00069 6.1 Kd ChEMBL;BindingDB
Q12866 MERTK Homo sapiens Human PF00041 PF00047 PF13927 PF07714 6.1 Kd ChEMBL;BindingDB
Q14289 PTK2B Homo sapiens Human PF21477 PF00373 PF18038 PF03623 PF07714 6.1 Kd ChEMBL;BindingDB
O94806 PRKD3 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 6.1 Kd ChEMBL;BindingDB
Q13237 PRKG2 Homo sapiens Human PF00027 PF00069 6.1 Kd ChEMBL;BindingDB
P29320 EPHA3 Homo sapiens Human PF14575 PF25599 PF01404 PF07699 PF00041 PF07714 PF07647 6.1 Kd ChEMBL;BindingDB
P52564 MAP2K6 Homo sapiens Human PF00069 6.1 Kd ChEMBL;BindingDB
Q04912 MST1R Homo sapiens Human PF07714 PF01437 PF01403 PF01833 6.1 Kd ChEMBL;BindingDB
Q00536 CDK16 Homo sapiens Human PF00069 6.1 Kd ChEMBL;BindingDB
P21802 FGFR2 Homo sapiens Human PF07679 PF13927 PF07714 6.1 Kd ChEMBL;BindingDB
P36507 MAP2K2 Homo sapiens Human PF00069 6.1 Kd ChEMBL;BindingDB
O94921 CDK14 Homo sapiens Human PF00069 6.1 Kd ChEMBL;BindingDB
Q16513 PKN2 Homo sapiens Human PF02185 PF00069 PF00433 6.1 Kd ChEMBL;BindingDB
Q9UEW8 STK39 Homo sapiens Human PF12202 PF00069 6.0 Kd ChEMBL;BindingDB
P08069 IGF1R Homo sapiens Human PF00757 PF07714 PF01030 6.0 Kd ChEMBL;BindingDB
P29376 LTK Homo sapiens Human PF12810 PF07714 6.0 Kd ChEMBL;BindingDB
P43403 ZAP70 Homo sapiens Human PF07714 PF00017 6.0 Kd ChEMBL;BindingDB
Q9Y463 DYRK1B Homo sapiens Human PF00069 6.0 Kd ChEMBL;BindingDB
P51956 NEK3 Homo sapiens Human PF00069 6.0 Kd ChEMBL;BindingDB
Q06187 BTK Homo sapiens Human PF00779 PF00169 PF07714 PF00017 PF00018 6.0 Kd ChEMBL;BindingDB
Q8NE63 HIPK4 Homo sapiens Human PF00069 6.0 Kd ChEMBL;BindingDB
Q9H2K8 TAOK3 Homo sapiens Human PF00069 6.0 Kd ChEMBL;BindingDB
P9WI81 pknB Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) Pathogen PF03793 PF00069 6.6 Kd ChEMBL;BindingDB