Molecule Details
| InChIKey | YWTBGJGMTBHQTM-IBGZPJMESA-N |
|---|---|
| Compound Name | A-443654 |
| Canonical SMILES | Cc1n[nH]c2ccc(-c3cncc(OC[C@@H](N)Cc4c[nH]c5ccccc45)c3)cc12 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 3 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 8.2 |
| Source | BindingDB;ChEMBL |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB08073 |
|---|---|
| Drug Name | (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE |
| CAS Number | nan |
| Groups | experimental |
| ATC Codes | nan |
| Description | nan |
Cross-references: BindingDB: 15131 ChEBI: 91351 CHEMBL379300 ChemSpider: 8348448 PDB: L20 PubChem:10172943 PubChem:99444544 ZINC: ZINC000016052239
Target Activities (3)
DrugBank Target Actions (5)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P17612 | PRKACA | cAMP-dependent protein kinase catalytic subunit alpha | binder | targets |
| P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | binder | targets |
| P49841 | GSK3B | Glycogen synthase kinase-3 beta | binder | targets |
| P61925 | P61925 | cAMP-dependent protein kinase inhibitor alpha | binder | targets |
| P31749 | AKT1 | RAC-alpha serine/threonine-protein kinase | inhibitor | targets |