Molecule Details
| InChIKey | YWLVSEKLYMROTP-UHFFFAOYSA-N |
|---|---|
| Compound Name | 6-[3-(1-Quinolin-2-ylazetidin-3-yl)oxypyrazin-2-yl]quinazolin-2-amine |
| Canonical SMILES | Nc1ncc2cc(-c3nccnc3OC3CN(c4ccc5ccccc5n4)C3)ccc2n1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 6.85 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| Q9Y233 | PDE10A | Homo sapiens | Human | PF01590 PF00233 | 8.2 | IC50 | ChEMBL;BindingDB |
| Q14432 | PDE3A | Homo sapiens | Human | PF00233 | 6.7 | IC50 | ChEMBL;BindingDB |
| Q01064 | PDE1B | Homo sapiens | Human | PF00233 PF08499 | 6.3 | IC50 | ChEMBL;BindingDB |
| Q08499 | PDE4D | Homo sapiens | Human | PF18100 PF00233 | 6.2 | IC50 | ChEMBL;BindingDB |