Molecule Details
InChIKeyYVUQSNJEYSNKRX-UHFFFAOYSA-N
Compound NamePimozide
Canonical SMILESO=c1[nH]c2ccccc2n1C1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)36
Pfam Stratification Cross-Family
Avg pChEMBL7.1
SourceBindingDB;ChEMBL
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB01100
Drug NamePimozide
CAS Number2062-78-4
Groups approved
ATC Codes N05AG02
DescriptionA diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postula...
Categories: Agents that reduce seizure threshold Anti-Dyskinesia Agents Antipsychotic Agents Antipsychotic Agents (First Generation [Typical]) Benzimidazoles Central Nervous System Agents Central Nervous System Depressants Cytochrome P-450 CYP1A2 Substrates Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (strength unknown) Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A4 Substrates (strength unknown) Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic Index Cytochrome P-450 CYP3A7 Substrates Cytochrome P-450 CYP3A7 Substrates with a Narrow Therapeutic Index Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Diphenylbutylpiperidine Derivatives Dopamine Agents Dopamine Antagonists Dopamine D2 Receptor Antagonists Heterocyclic Compounds, Fused-Ring Highest Risk QTc-Prolonging Agents Miscellaneous Antipsychotics Narrow Therapeutic Index Drugs Nervous System Neurotoxic agents Neurotransmitter Agents P-glycoprotein inhibitors Psycholeptics Psychotropic Drugs QTc Prolonging Agents Tranquilizing Agents
Cross-references: BindingDB: 50334150 ChEBI: 8212 CHEMBL1423 ChemSpider: 15520 Drugs Product Database (DPD): 7944 Guide to Pharmacology: 90 IUPHAR: 90 C07566 D00560 PDB: 1II PharmGKB: PA450965 PubChem:16362 PubChem:46507096 RxCUI: 8331 Therapeutic Targets Database: DAP000316 Wikipedia: Pimozide ZINC: ZINC000004175630
Target Activities (36)
Target Gene Organism Category Pfam pChEMBL Type Source
P34969 HTR7 Homo sapiens Human PF00001 9.3 Ki BindingDB
P35462 DRD3 Homo sapiens Human PF00001 9.0 Ki ChEMBL;BindingDB
P21917 DRD4 Homo sapiens Human PF00001 8.7 Ki BindingDB
P41595 HTR2B Homo sapiens Human PF00001 8.6 IC50 ChEMBL
P14416 DRD2 Homo sapiens Human PF00001 8.0 Ki ChEMBL;BindingDB
P28223 HTR2A Homo sapiens Human PF00001 7.8 Ki ChEMBL;BindingDB
Q12809 KCNH2 Homo sapiens Human PF00027 PF00520 PF13426 7.7 IC50 ChEMBL;BindingDB
O43497 CACNA1G Homo sapiens Human PF00520 7.4 Kd ChEMBL;BindingDB
P35498 SCN1A Homo sapiens Human PF00520 PF24609 PF06512 PF11933 7.3 IC50 ChEMBL
P35499 SCN4A Homo sapiens Human PF00520 PF24609 PF06512 7.3 IC50 ChEMBL
Q01118 SCN7A Homo sapiens Human PF00520 PF24609 PF06512 7.3 IC50 ChEMBL;BindingDB
Q14524 SCN5A Homo sapiens Human PF00520 PF24609 PF06512 PF11933 7.3 IC50 ChEMBL
Q15858 SCN9A Homo sapiens Human PF00520 PF24609 PF06512 PF11933 7.3 IC50 ChEMBL
Q99250 SCN2A Homo sapiens Human PF00520 PF24609 PF06512 PF11933 7.3 IC50 ChEMBL
Q9NY46 SCN3A Homo sapiens Human PF00520 PF24609 PF06512 PF11933 7.3 IC50 ChEMBL
Q9UI33 SCN11A Homo sapiens Human PF00520 PF24609 PF06512 7.3 IC50 ChEMBL
Q9UQD0 SCN8A Homo sapiens Human PF00520 PF24609 PF06512 PF11933 7.3 IC50 ChEMBL
Q9Y5Y9 SCN10A Homo sapiens Human PF00520 PF24609 PF06512 7.3 IC50 ChEMBL
P50406 HTR6 Homo sapiens Human PF00001 7.2 Ki ChEMBL;BindingDB
P35348 ADRA1A Homo sapiens Human PF00001 6.9 Ki BindingDB
P35367 HRH1 Homo sapiens Human PF00001 6.9 Ki BindingDB
O95180 CACNA1H Homo sapiens Human PF00520 6.8 IC50 ChEMBL
O60840 CACNA1F Homo sapiens Human PF08763 PF16885 PF16905 PF00520 6.7 IC50 ChEMBL
Q01668 CACNA1D Homo sapiens Human PF08763 PF16885 PF16905 PF00520 6.7 IC50 ChEMBL
Q13698 CACNA1S Homo sapiens Human PF08763 PF16905 PF00520 6.7 IC50 ChEMBL
Q13936 CACNA1C Homo sapiens Human PF08763 PF16885 PF16905 PF00520 6.7 IC50 ChEMBL;BindingDB
P35372 OPRM1 Homo sapiens Human PF00001 6.4 IC50 ChEMBL;BindingDB
P18825 ADRA2C Homo sapiens Human PF00001 6.4 Ki BindingDB
P28335 HTR2C Homo sapiens Human PF00001 6.2 Ki ChEMBL;BindingDB
P21728 DRD1 Homo sapiens Human PF00001 6.2 Ki ChEMBL
P08908 HTR1A Homo sapiens Human PF00001 6.2 Ki BindingDB
P08913 ADRA2A Homo sapiens Human PF00001 6.2 Ki BindingDB
P08172 CHRM2 Homo sapiens Human PF00001 6.1 Ki BindingDB
P08183 ABCB1 Homo sapiens Human PF00664 PF00005 6.1 IC50 ChEMBL;BindingDB
P18089 ADRA2B Homo sapiens Human PF00001 6.1 Ki BindingDB
P41145 OPRK1 Homo sapiens Human PF00001 6.0 IC50 ChEMBL;BindingDB
DrugBank Target Actions (10)
Target Gene Target Name Action Type
P10635 CYP2D6 Cytochrome P450 2D6 inhibitor enzymes
P05177 CYP1A2 Cytochrome P450 1A2 substrate enzymes
P08684 CYP3A4 Cytochrome P450 3A4 substrate enzymes
P20815 CYP3A5 Cytochrome P450 3A5 substrate enzymes
P24462 CYP3A7 Cytochrome P450 3A7 substrate enzymes
P14416 DRD2 D(2) dopamine receptor antagonist targets
P35462 DRD3 D(3) dopamine receptor antagonist targets
P0DP23 CALM1 Calmodulin inhibitor targets
Q12809 KCNH2 Voltage-gated inwardly rectifying potassium channel KCNH2 inhibitor targets
P08183 ABCB1 ATP-dependent translocase ABCB1 inhibitor transporters