Molecule Details
| InChIKey | YSXKPIUOCJLQIE-UHFFFAOYSA-N |
|---|---|
| Compound Name | Biperiden |
| Canonical SMILES | OC(CCN1CCCCC1)(c1ccccc1)C1CC2C=CC1C2 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 5 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 8.08 |
| Source | BindingDB;ChEMBL |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB00810 |
|---|---|
| Drug Name | Biperiden |
| CAS Number | 514-65-8 |
| Groups | approved investigational withdrawn |
| ATC Codes | N04AA02 |
| Description | A muscarinic antagonist that has effects in both the central and peripheral nervous systems. It has been used in the treatment of arteriosclerotic, idiopathic, and postencephalitic parkinsonism. It has also been used to alleviate extrapyramidal symptoms induced by phenothiazine derivatives and reser... |
Categories: Agents producing tachycardia Anti-Dyskinesia Agents Anti-Parkinson Drugs Anticholinergic Agents Autonomic Agents Aza Compounds Azabicyclo Compounds Bridged-Ring Compounds Central Nervous System Agents Cholinergic Agents Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (strength unknown) Cytochrome P-450 Enzyme Inhibitors Muscarinic Antagonists Nervous System Neurotransmitter Agents Nicotinic Antagonists Parasympatholytics Peripheral Nervous System Agents Piperidines Tertiary Amines
Cross-references: BindingDB: 50240680 ChEBI: 3112 CHEMBL1101 ChemSpider: 2289 Drugs Product Database (DPD): 6471 C07941 D00779 PharmGKB: PA448626 PubChem:2381 PubChem:46508325 RxCUI: 1589 Therapeutic Targets Database: DAP001125 Wikipedia: Biperiden
Target Activities (5)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P11229 | CHRM1 | Homo sapiens | Human | PF00001 | 8.6 | Ki | ChEMBL;BindingDB |
| P20309 | CHRM3 | Homo sapiens | Human | PF00001 | 8.2 | Ki | ChEMBL;BindingDB |
| P08912 | CHRM5 | Homo sapiens | Human | PF00001 | 8.2 | Ki | BindingDB |
| P08172 | CHRM2 | Homo sapiens | Human | PF00001 | 7.9 | Ki | ChEMBL;BindingDB |
| P08173 | CHRM4 | Homo sapiens | Human | PF00001 | 7.5 | Ki | ChEMBL;BindingDB |