Molecule Details
| InChIKey | YRFOQHHFWYWAST-UHFFFAOYSA-N |
|---|---|
| Compound Name | Cdk8/19-IN-2 |
| Canonical SMILES | FC(F)c1c(Br)c(Br)cc2c1nc(N1CCNCC1)n2C1CCOCC1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 22 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 7.33 |
| Source | ChEMBL |
2D Structure
Activity Profile
Target Activities (22)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| Q9HAZ1 | CLK4 | Homo sapiens | Human | PF00069 | 8.5 | IC50 | ChEMBL |
| P24863 | CCNC | Homo sapiens | Human | PF16899 PF00134 | 8.4 | IC50 | ChEMBL |
| P49336 | CDK8 | Homo sapiens | Human | PF00069 | 8.4 | IC50 | ChEMBL |
| Q9BWU1 | CDK19 | Homo sapiens | Human | PF00069 | 8.1 | IC50 | ChEMBL |
| P49759 | CLK1 | Homo sapiens | Human | PF00069 | 8.1 | IC50 | ChEMBL |
| Q8TF76 | HASPIN | Homo sapiens | Human | PF12330 | 7.9 | IC50 | ChEMBL |
| P49760 | CLK2 | Homo sapiens | Human | PF00069 | 7.8 | IC50 | ChEMBL |
| P24864 | CCNE1 | Homo sapiens | Human | PF02984 PF00134 | 7.5 | IC50 | ChEMBL |
| P24941 | CDK2 | Homo sapiens | Human | PF00069 | 7.4 | IC50 | ChEMBL |
| P20248 | CCNA2 | Homo sapiens | Human | PF02984 PF00134 PF16500 | 7.4 | IC50 | ChEMBL |
| Q8TD08 | MAPK15 | Homo sapiens | Human | PF00069 | 7.2 | IC50 | ChEMBL |
| P19784 | CSNK2A2 | Homo sapiens | Human | PF00069 | 7.2 | IC50 | ChEMBL |
| Q9P1W9 | PIM2 | Homo sapiens | Human | PF00069 | 6.9 | IC50 | ChEMBL |
| P48729 | CSNK1A1 | Homo sapiens | Human | PF00069 | 6.9 | IC50 | ChEMBL |
| Q00535 | CDK5 | Homo sapiens | Human | PF00069 | 6.9 | IC50 | ChEMBL |
| Q15078 | CDK5R1 | Homo sapiens | Human | PF03261 | 6.9 | IC50 | ChEMBL |
| Q13627 | DYRK1A | Homo sapiens | Human | PF00069 | 6.8 | IC50 | ChEMBL |
| P50613 | CDK7 | Homo sapiens | Human | PF00069 | 6.7 | IC50 | ChEMBL |
| P51946 | CCNH | Homo sapiens | Human | PF16899 PF00134 | 6.7 | IC50 | ChEMBL |
| P51948 | MNAT1 | Homo sapiens | Human | PF25811 PF06391 PF17121 | 6.7 | IC50 | ChEMBL |
| Q13464 | ROCK1 | Homo sapiens | Human | PF25346 PF00069 PF08912 | 6.5 | IC50 | ChEMBL |
| Q9H422 | HIPK3 | Homo sapiens | Human | PF00069 | 6.3 | IC50 | ChEMBL |