InChIKey	YREYEVIYCVEVJK-UHFFFAOYSA-N
Compound Name	Rabeprazole
Canonical SMILES	COCCCOc1ccnc(C[S+]([O-])c2nc3ccccc3[nH]2)c1C
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	6
Pfam Stratification	Cross-Family
Avg pChEMBL	6.32
Source	ChEMBL;BindingDB

DrugBank ID	DB01129
Drug Name	Rabeprazole
CAS Number	117976-89-3
Groups	approved investigational
ATC Codes	A02BD12 A02BD13 A02BC54 A02BC04
Description	Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastri...

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Categories: 2-Pyridinylmethylsulfinylbenzimidazoles Acetates Acid Reducers Acids, Acyclic Alimentary Tract and Metabolism Anti-Ulcer Agents Antiinflammatory Preparations, Non-Steroids for Topical Use Antiinflammatory and Antirheumatic Products Antiinflammatory and Antirheumatic Products, Non-Steroids BCRP/ABCG2 Inhibitors Benzimidazoles Butylpyrazolidines Cytochrome P-450 CYP1A2 Inducers Cytochrome P-450 CYP1A2 Inducers (strength unknown) Cytochrome P-450 CYP1A2 Inhibitors Cytochrome P-450 CYP1A2 Inhibitors (strength unknown) Cytochrome P-450 CYP2C19 Inhibitors Cytochrome P-450 CYP2C19 Substrates Cytochrome P-450 CYP2C19 inhibitors (strength unknown) Cytochrome P-450 CYP2C8 Inhibitors Cytochrome P-450 CYP2C8 Inhibitors (moderate) Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (strength unknown) Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (weak) Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Drugs for Acid Related Disorders Drugs for Peptic Ulcer and Gastro-Oesophageal Reflux Disease (Gord) Drugs that are Mainly Renally Excreted Enzyme Inhibitors Gastric Acid Lowering Agents Gastrointestinal Agents Heterocyclic Compounds, Fused-Ring Hydroxy Acids Musculo-Skeletal System Proton Pump Inhibitors Proton-pump Inhibitors Pyrazoles Pyrazolones Pyridines Sulfoxides Sulfur Compounds Topical Products for Joint and Muscular Pain

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Cross-references: BindingDB: 651963 ChEBI: 8768 CHEMBL1219 ChemSpider: 4853 Drugs Product Database (DPD): 12149 C07864 D08463 PharmGKB: PA451216 PubChem:5029 PubChem:46506366 RxCUI: 114979 Therapeutic Targets Database: DAP000727 Wikipedia: Rabeprazole