Molecule Details
InChIKeyYQKSNDNARJQAHP-UHFFFAOYSA-N
Compound Name7-Chloro-8-(3-hydroxypropoxy)-3-oxo-11,17-dioxa-2,4,20,22-tetraazatricyclo[16.3.1.0^{5,10}]docosa-1(21),5(10),6,8,18(22),19-hexaene-19-carbonitrile
Canonical SMILESN#Cc1ncc2nc1OCCCCCOc1cc(OCCCO)c(Cl)cc1NC(=O)N2
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)12
Pfam Stratification Cross-Family
Avg pChEMBL6.77
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
Target Activities (12)
Target Gene Organism Category Pfam pChEMBL Type Source
O14757 CHEK1 Homo sapiens Human PF00069 8.5 IC50 ChEMBL;BindingDB
P51812 RPS6KA3 Homo sapiens Human PF00069 PF00433 7.9 Ki ChEMBL
P07333 CSF1R Homo sapiens Human PF00047 PF25305 PF07714 7.4 Ki ChEMBL
Q13188 STK3 Homo sapiens Human PF11629 PF00069 7.3 Ki ChEMBL
P27448 MARK3 Homo sapiens Human PF02149 PF00069 PF00627 6.8 Ki ChEMBL
P49841 GSK3B Homo sapiens Human PF00069 6.6 Ki ChEMBL
O14920 IKBKB Homo sapiens Human PF18397 PF12179 PF00069 6.5 Ki ChEMBL
Q9H4B4 PLK3 Homo sapiens Human PF00069 PF00659 6.1 Ki ChEMBL
P49137 MAPKAPK2 Homo sapiens Human PF00069 6.1 Ki ChEMBL
P11309 PIM1 Homo sapiens Human PF00069 6.0 Ki ChEMBL
P31749 AKT1 Homo sapiens Human PF00169 PF00069 PF00433 6.0 Ki ChEMBL
P31751 AKT2 Homo sapiens Human PF00169 PF00069 PF00433 6.0 Ki ChEMBL