InChIKey	YQEZLKZALYSWHR-ZDUSSCGKSA-N
Compound Name	Esketamine
Canonical SMILES	CN[C@]1(c2ccccc2Cl)CCCCC1=O
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	2
Pfam Stratification	Homologous
Avg pChEMBL	7.94
Source	ChEMBL

DrugBank ID	DB11823
Drug Name	Esketamine
CAS Number	33643-46-8
Groups	approved investigational
ATC Codes	N06AX27 N01AX14
Description	Major depressive disorder (MDD) is a significant cause of disability worldwide and the most common illness preceding suicide.[L5596,A175462] On March 5, 2019, the nasal spray drug, _esketamine_, also known as _Spravato_ (by Janssen Pharmaceuticals), was approved by the FDA for treatment-resistant ma...

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Categories: Agents producing tachycardia Anesthetics Anesthetics, General Antidepressive Agents Antidepressive Agents Indicated for Depression Central Nervous System Agents Central Nervous System Depressants Cyclohexanes Cycloparaffins Cytochrome P-450 CYP2B6 Inducers Cytochrome P-450 CYP2B6 Inducers (weak) Cytochrome P-450 CYP2B6 Substrates Cytochrome P-450 CYP2C19 Substrates Cytochrome P-450 CYP2C9 Substrates Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (weak) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Substrates Miscellaneous Antidepressants NMDA Receptor Antagonists Nervous System Non-Competitive N-Methyl D-Aspartate (NMDA) Receptor Antagonists Psychoanaleptics Psychotropic Drugs

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Cross-references: ChEBI: 60799 CHEMBL395091 ChemSpider: 158414 Drugs Product Database (DPD): 23459 D07283 PDB: JC9 PubChem:182137 PubChem:347828170 RxCUI: 2119365 Wikipedia: Esketamine ZINC: ZINC000035999642