Molecule Details
| InChIKey | YPHMISFOHDHNIV-FSZOTQKASA-N |
|---|---|
| Compound Name | Cycloheximide |
| Canonical SMILES | C[C@@H]1C[C@@H]([C@H](O)CC2CC(=O)NC(=O)C2)C(=O)[C@@H](C)C1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 6 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 6.93 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB20401 |
|---|---|
| Drug Name | Cycloheximide |
| CAS Number | 66-81-9 |
| Groups | experimental |
| ATC Codes | nan |
| Description | Cycloheximide is a small molecule drug. Cycloheximide has a monoisotopic molecular weight of 281.16 Da. |
Categories: Anti-Infective Agents Antifungal Agents Enzyme Inhibitors Piperidines Piperidones Protein Synthesis Inhibitors
Cross-references: BindingDB: 50080528 ChEBI: 27641 CHEMBL123292 C06685 PDB: 3HE ZINC: ZINC000003872170
Target Activities (6)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| Q16665 | HIF1A | Homo sapiens | Human | PF23171 PF11413 PF08778 PF00989 PF08447 | 7.4 | IC50 | ChEMBL;BindingDB |
| Q99814 | EPAS1 | Homo sapiens | Human | PF23171 PF11413 PF08778 PF00989 PF14598 | 7.4 | IC50 | ChEMBL |
| P60842 | EIF4A1 | Homo sapiens | Human | PF00270 PF00271 | 6.9 | IC50 | ChEMBL;BindingDB |
| P11166 | SLC2A1 | Homo sapiens | Human | PF00083 | 6.6 | IC50 | ChEMBL |
| O61059 | LmGT2 | Leishmania mexicana | Pathogen | PF00083 | 6.6 | IC50 | ChEMBL |
| O97467 | ht1 | Plasmodium falciparum | Pathogen | PF00083 | 6.5 | IC50 | ChEMBL |