InChIKey	YOSHYTLCDANDAN-UHFFFAOYSA-N
Compound Name	Irbesartan
Canonical SMILES	CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	2
Pfam Stratification	Homologous
Avg pChEMBL	8.61
Source	ChEMBL;BindingDB

DrugBank ID	DB01029
Drug Name	Irbesartan
CAS Number	138402-11-6
Groups	approved investigational
ATC Codes	C09CA04 C09DB05 C09DA04 C09DX07
Description	Irbesartan is an angiotensin receptor blocker (ARB) indicated to treat hypertension or diabetic nephropathy.[L7456,L7459] It can also be used as part of a combination product with [hydrochlorothiazide] for patients not well controlled or not expected to be well controlled on monotherapy.[L7459] Unli...

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Categories: Agents Acting on the Renin-Angiotensin System Agents causing hyperkalemia Angiotensin 2 Receptor Blocker Angiotensin II Type 2 Receptor Blockers Angiotensin II receptor antagonists Angiotensin II receptor blockers (ARBs) and calcium channel blockers Angiotensin II receptor blockers (ARBs) and diuretics Angiotensin II receptor blockers (ARBs), plain Angiotensin Receptor Antagonists Antihypertensive Agents Antihypertensive Agents Indicated for Hypertension Benzene Derivatives Biphenyl Compounds Cardiovascular Agents Cytochrome P-450 CYP2C8 Inhibitors Cytochrome P-450 CYP2C8 Inhibitors (moderate) Cytochrome P-450 CYP2C8 Substrates Cytochrome P-450 CYP2C9 Substrates Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Hypotensive Agents Spiro Compounds Tetrazoles UGT1A3 substrates

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Cross-references: BindingDB: 50042235 ChEBI: 5959 CHEMBL1513 ChemSpider: 3618 Drugs Product Database (DPD): 11776 Guide to Pharmacology: 589 IUPHAR: 589 C07469 D00523 PharmGKB: PA450084 PubChem:3749 PubChem:46506575 RxCUI: 83818 Therapeutic Targets Database: DAP000364 Wikipedia: Irbesartan ZINC: ZINC000003872931