Molecule Details
| InChIKey | YONOBYIBNBCDSJ-UHFFFAOYSA-N |
|---|---|
| Compound Name | Forasartan |
| Canonical SMILES | CCCCc1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nnn[nH]3)nc2)n1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 2 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 8.18 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB01342 |
|---|---|
| Drug Name | Forasartan |
| CAS Number | 145216-43-9 |
| Groups | experimental |
| ATC Codes | nan |
| Description | Forasartan, a specific angiotensin II antagonist, is used alone or with other antihypertensive agents to treat hypertension. Forasartan competes with angiotensin II for binding at the AT1 receptor subtype. As angiotensin II is a vasoconstrictor which also stimulates the synthesis and release of aldo... |
Categories: Agents Acting on the Renin-Angiotensin System Agents causing angioedema Agents causing hyperkalemia Angiotensin II Type 1 Receptor Blockers Angiotensin II receptor antagonists Angiotensin Receptor Antagonists
Cross-references: BindingDB: 50049209 ChEBI: 141552 CHEMBL315021 ChemSpider: 117146 D04243 PharmGKB: PA164776845 PubChem:132706 PubChem:46505698 Therapeutic Targets Database: DAP001256 Wikipedia: Forasartan ZINC: ZINC000005139136
Target Activities (2)
DrugBank Target Actions (1)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P30556 | AGTR1 | Type-1 angiotensin II receptor | antagonist | targets |