Molecule Details
| InChIKey | YOKGFEAEVZNOAR-UHFFFAOYSA-N |
|---|---|
| Compound Name | 5-(4-acetyl-1H-pyrrol-2-yl)-2-[cyclopropyl-[1-[3-(hydroxymethyl)-4-pyridinyl]pyrazol-4-yl]amino]-1,3-thiazole-4-carboxamide |
| Canonical SMILES | CC(=O)c1c[nH]c(-c2sc(N(c3cnn(-c4ccncc4CO)c3)C3CC3)nc2C(N)=O)c1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 5 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 7.49 |
| Source | ChEMBL |
2D Structure
Activity Profile
Target Activities (5)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P36896 | ACVR1B | Homo sapiens | Human | PF01064 PF00069 PF08515 | 8.3 | IC50 | ChEMBL |
| P36897 | TGFBR1 | Homo sapiens | Human | PF01064 PF00069 PF08515 | 8.2 | IC50 | ChEMBL |
| Q13705 | ACVR2B | Homo sapiens | Human | PF01064 PF00069 | 7.2 | IC50 | ChEMBL |
| Q04771 | ACVR1 | Homo sapiens | Human | PF01064 PF07714 PF08515 | 7.1 | IC50 | ChEMBL |
| P37023 | ACVRL1 | Homo sapiens | Human | PF07714 PF08515 | 6.6 | IC50 | ChEMBL |