InChIKey	YMARZQAQMVYCKC-OEMFJLHTSA-N
Compound Name	Amprenavir
Canonical SMILES	CC(C)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)O[C@H]1CCOC1)S(=O)(=O)c1ccc(N)cc1
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	6
Pfam Stratification	Cross-Family
Avg pChEMBL	8.24
Source	BindingDB;ChEMBL

DrugBank ID	DB00701
Drug Name	Amprenavir
CAS Number	161814-49-9
Groups	approved withdrawn
ATC Codes	J05AE05
Description	Amprenavir is a protease inhibitor used to treat HIV infection.

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Categories: Acids, Acyclic Amides Amprenavir and Prodrugs Anti-HIV Agents Anti-Infective Agents Anti-Retroviral Agents Antibiotics, Antitubercular Antiinfectives for Systemic Use Antiviral Agents Antivirals for Systemic Use Cytochrome P-450 CYP2B6 Inhibitors Cytochrome P-450 CYP2B6 Inhibitors (weak) Cytochrome P-450 CYP2C19 Inhibitors Cytochrome P-450 CYP2C19 inhibitors (strength unknown) Cytochrome P-450 CYP2C9 Substrates Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (strength unknown) Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 CYP3A4 Inhibitors (strong) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Direct Acting Antivirals Drugs for Treatment of Tuberculosis Enzyme Inhibitors HIV Protease Inhibitors OATP1B1/SLCO1B1 Inhibitors P-glycoprotein inducers P-glycoprotein substrates Protease Inhibitors Sulfones Sulfur Compounds Viral Protease Inhibitors

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Cross-references: BindingDB: 577 ChEBI: 40050 CHEMBL116 ChemSpider: 58532 Drugs Product Database (DPD): 12083 C08086 D00894 PDB: 478 PharmGKB: PA448422 PubChem:65016 PubChem:46507537 RxCUI: 228656 Therapeutic Targets Database: DAP000170 Wikipedia: Amprenavir ZINC: ZINC000003809192