Molecule Details
InChIKeyYJVWRVUQZNYKON-UHFFFAOYSA-N
Compound NameJak/hdac-IN-2
Canonical SMILESCc1cnc(Nc2ccc(OCCCCCCC(=O)NO)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)15
Pfam Stratification Cross-Family
Avg pChEMBL8.57
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (15)
Target Gene Organism Category Pfam pChEMBL Type Source
P56524 HDAC4 Homo sapiens Human PF12203 PF00850 9.8 IC50 ChEMBL
Q8WUI4 HDAC7 Homo sapiens Human PF00850 9.8 IC50 ChEMBL
Q9BY41 HDAC8 Homo sapiens Human PF00850 9.8 IC50 ChEMBL
Q9UKV0 HDAC9 Homo sapiens Human PF12203 PF00850 9.8 IC50 ChEMBL
Q9UQL6 HDAC5 Homo sapiens Human PF12203 PF00850 9.8 IC50 ChEMBL
Q13547 HDAC1 Homo sapiens Human PF00850 9.6 IC50 ChEMBL
Q9UBN7 HDAC6 Homo sapiens Human PF00850 PF02148 9.1 IC50 ChEMBL
O15379 HDAC3 Homo sapiens Human PF00850 8.5 IC50 ChEMBL
Q969S8 HDAC10 Homo sapiens Human PF00850 8.3 IC50 ChEMBL
Q92769 HDAC2 Homo sapiens Human PF00850 8.1 IC50 ChEMBL
O60674 JAK2 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 8.0 IC50 ChEMBL
Q96DB2 HDAC11 Homo sapiens Human PF00850 8.0 IC50 ChEMBL
P23458 JAK1 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 7.6 IC50 ChEMBL
P29597 TYK2 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 6.4 IC50 ChEMBL
P52333 JAK3 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 6.2 IC50 ChEMBL