Molecule Details
InChIKeyYJGKHEQGTLAYHU-UHFFFAOYSA-N
Compound Name4-amino-N-(6'-oxo-7',8'-dihydro-6'H-spiro[cyclohexane-1,9'-pyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidin]-2'-yl)benzenesulfonamide
Canonical SMILESNc1ccc(S(=O)(=O)Nc2ncc3cc4n(c3n2)C2(CCCCC2)CNC4=O)cc1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)9
Pfam Stratification Cross-Family
Avg pChEMBL6.44
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
Target Activities (9)
Target Gene Organism Category Pfam pChEMBL Type Source
O60563 CCNT1 Homo sapiens Human PF00134 PF21797 6.7 IC50 ChEMBL;BindingDB
P50750 CDK9 Homo sapiens Human PF00069 6.7 IC50 ChEMBL
P24864 CCNE1 Homo sapiens Human PF02984 PF00134 6.5 IC50 ChEMBL
P24941 CDK2 Homo sapiens Human PF00069 6.5 IC50 ChEMBL;BindingDB
P20248 CCNA2 Homo sapiens Human PF02984 PF00134 PF16500 6.5 IC50 ChEMBL
P11802 CDK4 Homo sapiens Human PF00069 6.4 IC50 ChEMBL;BindingDB
P24385 CCND1 Homo sapiens Human PF02984 PF00134 6.4 IC50 ChEMBL
P30281 CCND3 Homo sapiens Human PF02984 PF00134 6.0 IC50 ChEMBL
Q00534 CDK6 Homo sapiens Human PF00069 6.0 IC50 ChEMBL;BindingDB