Molecule Details
InChIKeyYGSDEFSMJLZEOE-UHFFFAOYSA-N
Compound NameSalicylic Acid
Canonical SMILESO=C(O)c1ccccc1O
Clinical Status Clinical Multi-Target
Targets (Human+Pathogen)3
Pfam Stratification Cross-Family
Avg pChEMBL7.9
SourceChEMBL;BindingDB;TTD_MultiTarget
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB00936
Drug NameSalicylic acid
CAS Number69-72-7
Groups approved investigational vet_approved
ATC Codes D01AE12 G04BX17 N02BA04 N02BA12 S01BC08
DescriptionA compound obtained from the bark of the white willow and wintergreen leaves, and also prepared synthetically. It has bacteriostatic, fungicidal, and keratolytic actions. Its salts, the salicylates, are used as analgesics.

Categories: Acids, Carbocyclic Agents causing hyperkalemia Agents that produce hypertension Analgesics Analgesics, Non-Narcotic Anti-Infective Agents Anti-Inflammatory Agents Anti-Inflammatory Agents, Non-Steroidal Anti-Inflammatory Agents, Non-Steroidal (Non-Selective) Antifungal Agents Antifungals for Dermatological Use Antifungals for Topical Use Benzene Derivatives Benzoates Cyclooxygenase Inhibitors Cytochrome P-450 CYP2C9 Substrates Cytochrome P-450 Substrates Dermatologicals Enzyme Inhibitors Genito Urinary System and Sex Hormones Hydroxy Acids Hydroxybenzoates Keratolytic Agents Nephrotoxic agents Nervous System Non COX-2 selective NSAIDS OAT1/SLC22A6 inhibitors OAT3/SLC22A8 Inhibitors OATP2B1/SLCO2B1 substrates Ophthalmologicals Peripheral Nervous System Agents Phenols Salicylates Salicylic Acid and Derivatives Sclerosing Solutions Sensory Organs Sensory System Agents Urologicals
Cross-references: BindingDB: 26193 ChEBI: 16914 CHEMBL424 ChemSpider: 331 Drugs Product Database (DPD): 9766 Guide to Pharmacology: 4306 IUPHAR: 4306 C00805 D00097 PDB: SAL PharmGKB: PA451299 PubChem:338 PubChem:46504942 RxCUI: 9525 Therapeutic Targets Database: DAP000731 Wikipedia: Salicylic_acid ZINC: ZINC000000001554
Target Activities (3)
Target Gene Organism Category Pfam pChEMBL Type Source
Q6XQN6 NAPRT Homo sapiens Human PF17956 PF17767 9.8 Ki ChEMBL
P09429 HMGB1 Homo sapiens Human PF00505 PF09011 6.0 Kd ChEMBL;BindingDB
P18505 GABRB1 Homo sapiens Human PF02931 PF02932 Clinical TTD_MultiTarget TTD_MultiTarget
DrugBank Target Actions (17)
Target Gene Target Name Action Type
P02768 ALB Albumin other/unknown carriers
P11712 CYP2C9 Cytochrome P450 2C9 substrate enzymes
O43570 CA12 Carbonic anhydrase 12 inhibitor targets
P00915 CA1 Carbonic anhydrase 1 inhibitor targets
P00918 CA2 Carbonic anhydrase 2 inhibitor targets
P22748 CA4 Carbonic anhydrase 4 inhibitor targets
P23219 PTGS1 Prostaglandin G/H synthase 1 inhibitor targets
P23280 CA6 Carbonic anhydrase 6 inhibitor targets
P35354 PTGS2 Prostaglandin G/H synthase 2 inhibitor targets
Q04828 AKR1C1 Aldo-keto reductase family 1 member C1 inhibitor targets
Q4U2R8 SLC22A6 Solute carrier family 22 member 6 inhibitor transporters
Q63ZE4 Q63ZE4 Solute carrier family 22 member 10 inhibitor transporters
Q8TCC7 SLC22A8 Organic anion transporter 3 inhibitor transporters
Q9NSA0 SLC22A11 Solute carrier family 22 member 11 inhibitor transporters
O94956 SLCO2B1 Solute carrier organic anion transporter family member 2B1 substrate transporters
P53985 SLC16A1 Monocarboxylate transporter 1 substrate transporters
Q9Y694 Q9Y694 Solute carrier family 22 member 7 substrate transporters