Molecule Details
InChIKeyYEZNLOUZAIOMLT-UHFFFAOYSA-N
Compound NameTolfenamic Acid
Canonical SMILESCc1c(Cl)cccc1Nc1ccccc1C(=O)O
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)3
Pfam Stratification Cross-Family
Avg pChEMBL6.99
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB09216
Drug NameTolfenamic acid
CAS Number13710-19-5
Groups approved
ATC Codes M01AG02
DescriptionTolfenamic acid, with the formula N-(2-methyl-3-chlorphenyl)-anthranilic acid, is a nonsteroidal anti-inflammatory agent.[A31824] It was discovered by scientists at Medica Pharmaceutical Company in Finland. It is used in the UK as a treatment for migraine under the name of Clotam.[L1292] In the US, ...

Categories: Acids, Carbocyclic Agents causing hyperkalemia Agents that produce hypertension Aminobenzoates Analgesics Analgesics, Non-Narcotic Anti-Inflammatory Agents Anti-Inflammatory Agents, Non-Steroidal Antiinflammatory and Antirheumatic Products Antiinflammatory and Antirheumatic Products, Non-Steroids Antirheumatic Agents Benzene Derivatives Benzoates Bradycardia-Causing Agents Calcium-Regulating Hormones and Agents Cardiovascular Agents Central Nervous System Agents Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Substrates Fenamates Hormone Antagonists Hormones, Hormone Substitutes, and Hormone Antagonists Membrane Transport Modulators Migraine Disorders, drug therapy Musculo-Skeletal System Nephrotoxic agents Neurotransmitter Agents Non COX-2 selective NSAIDS Peripheral Nervous System Agents Prostaglandin Antagonists Sensory System Agents
Cross-references: BindingDB: 35905 ChEBI: 32243 CHEMBL121626 ChemSpider: 530683 Drugs Product Database (DPD): 928 D01183 PDB: TLF PharmGKB: PA166049189 PubChem:610479 PubChem:310265123 RxCUI: 38377 Wikipedia: Tolfenamic_acid ZINC: ZINC000000002188
Target Activities (3)
Target Gene Organism Category Pfam pChEMBL Type Source
P42330 AKR1C3 Homo sapiens Human PF00248 8.1 Ki ChEMBL;BindingDB
P02766 TTR Homo sapiens Human PF00576 6.8 Kd ChEMBL;BindingDB
P35354 PTGS2 Homo sapiens Human PF03098 6.1 IC50 ChEMBL;BindingDB
DrugBank Target Actions (3)
Target Gene Target Name Action Type
P08684 CYP3A4 Cytochrome P450 3A4 substrate enzymes
P23219 PTGS1 Prostaglandin G/H synthase 1 antagonist targets
P35354 PTGS2 Prostaglandin G/H synthase 2 antagonist targets