Molecule Details
InChIKeyYEKVTSRZMPLPFK-UHFFFAOYSA-N
Compound Name1-(6-Methylquinolin-4-yl)-3-[6-(trifluoromethyl)-2-pyridinyl]urea
Canonical SMILESCc1ccc2nccc(NC(=O)Nc3cccc(C(F)(F)F)n3)c2c1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)17
Pfam Stratification Cross-Family
Avg pChEMBL6.59
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (17)
Target Gene Organism Category Pfam pChEMBL Type Source
P24941 CDK2 Homo sapiens Human PF00069 7.1 Ki ChEMBL
P42685 FRK Homo sapiens Human PF07714 PF00017 PF00018 7.0 Ki ChEMBL
Q9HAZ1 CLK4 Homo sapiens Human PF00069 7.0 Ki ChEMBL
Q13188 STK3 Homo sapiens Human PF11629 PF00069 6.8 Ki ChEMBL
P49336 CDK8 Homo sapiens Human PF00069 6.7 Ki ChEMBL
Q8N4C8 MINK1 Homo sapiens Human PF00780 PF00069 6.7 Ki ChEMBL
P36888 FLT3 Homo sapiens Human PF00047 PF07714 6.6 Ki ChEMBL
P68400 CSNK2A1 Homo sapiens Human PF00069 6.6 Ki ChEMBL
Q8NE63 HIPK4 Homo sapiens Human PF00069 6.6 Ki ChEMBL
Q96GD4 AURKB Homo sapiens Human PF00069 6.6 Ki ChEMBL
Q00535 CDK5 Homo sapiens Human PF00069 6.5 Ki ChEMBL
Q04771 ACVR1 Homo sapiens Human PF01064 PF07714 PF08515 6.5 Ki ChEMBL
Q86V86 PIM3 Homo sapiens Human PF00069 6.5 Ki ChEMBL
Q13882 PTK6 Homo sapiens Human PF07714 PF00017 PF00018 6.4 Ki ChEMBL
P06493 CDK1 Homo sapiens Human PF00069 6.3 Ki ChEMBL
Q9H2X6 HIPK2 Homo sapiens Human PF00069 6.1 Ki ChEMBL
P35916 FLT4 Homo sapiens Human PF07679 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 6.0 Ki ChEMBL