Molecule Details
InChIKeyYDZYKNJZCVIKPP-VWLOTQADSA-N
Compound NameNetazepide
Canonical SMILESCNc1cccc(NC(=O)N[C@@H]2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)2
Pfam Stratification Homologous
Avg pChEMBL8.7
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB12355
Drug NameNetazepide
CAS Number155488-25-8
Groups investigational
ATC Codes nan
DescriptionNetazepide has been used in trials studying the prevention and treatment of Dyspepsia, Hypergastrinaemia, Barrett's Esophagus, ECL-cell Hyperplasia, and Rebound Hyperacidity, among others.
Categories: Amides Benzazepines Benzene Derivatives Heterocyclic Compounds, Fused-Ring Receptors, Cholecystokinin, antagonists & inhibitors
Cross-references: BindingDB: 50056102 CHEMBL324547 ChemSpider: 8046211 PubChem:9870520 PubChem:347828609 ZINC: ZINC000003810905
Target Activities (2)
Target Gene Organism Category Pfam pChEMBL Type Source
P32239 CCKBR Homo sapiens Human PF00001 9.9 Ki ChEMBL;BindingDB
P32238 CCKAR Homo sapiens Human PF00001 PF09193 7.5 Ki ChEMBL;BindingDB
DrugBank Target Actions (1)
Target Gene Target Name Action Type
P32239 CCKBR Gastrin/cholecystokinin type B receptor inhibitor targets