Molecule Details
| InChIKey | YDSDEBIZUNNPOB-UHFFFAOYSA-N |
|---|---|
| Compound Name | Carfentanil |
| Canonical SMILES | CCC(=O)N(c1ccccc1)C1(C(=O)OC)CCN(CCc2ccccc2)CC1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 9.15 |
| Source | BindingDB;ChEMBL |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB01535 |
|---|---|
| Drug Name | Carfentanil |
| CAS Number | 59708-52-0 |
| Groups | illicit investigational vet_approved |
| ATC Codes | nan |
| Description | Carfentanil or carfentanyl (Wildnil) is an analogue of the popular synthetic opioid analgesic fentanyl, and is one of the most potent opioids known (also the most potent opioid used commercially). Carfentanil was first synthesized in 1974 by a team of chemists at Janssen Pharmaceutica which included... |
Categories: Analgesics Carbon Radioisotopes Central Nervous System Agents Central Nervous System Depressants High-risk opioids Narcotics Opioids Peripheral Nervous System Agents Phenylpiperidine opioids Piperidines Sensory System Agents Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome
Cross-references: BindingDB: 50012477 ChEBI: 61084 CHEMBL290429 ChemSpider: 55986 Drugs Product Database (DPD): 11176 PDB: 84K PubChem:62156 PubChem:46505501 Wikipedia: Carfentanil ZINC: ZINC000004215196
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P35372 | OPRM1 | Homo sapiens | Human | PF00001 | 10.6 | Ki | ChEMBL;BindingDB |
| Q14982 | OPCML | Homo sapiens | Human | PF07679 PF13927 | 10.1 | Kd | BindingDB |
| P41143 | OPRD1 | Homo sapiens | Human | PF00001 | 8.5 | Ki | ChEMBL;BindingDB |
| P41145 | OPRK1 | Homo sapiens | Human | PF00001 | 7.4 | Ki | ChEMBL;BindingDB |