Molecule Details
InChIKeyYDOPLCNFRXOHCC-UHFFFAOYSA-N
Compound NameN-[(3,4-dimethoxyphenyl)methylideneamino]-5H-pyrimido[5,4-b]indol-4-amine
Canonical SMILESCOc1ccc(C=NNc2ncnc3c2[nH]c2ccccc23)cc1OC
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)28
Pfam Stratification Cross-Family
Avg pChEMBL6.81
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (28)
Target Gene Organism Category Pfam pChEMBL Type Source
P07333 CSF1R Homo sapiens Human PF00047 PF25305 PF07714 8.0 Ki ChEMBL
P06241 FYN Homo sapiens Human PF07714 PF00017 PF00018 7.9 Ki ChEMBL
P29317 EPHA2 Homo sapiens Human PF14575 PF25599 PF01404 PF00041 PF07714 PF00536 7.9 Ki ChEMBL
P07948 LYN Homo sapiens Human PF07714 PF00017 PF00018 7.6 Ki ChEMBL
P12931 SRC Homo sapiens Human PF07714 PF00017 PF00018 7.3 Ki ChEMBL
P00519 ABL1 Homo sapiens Human PF08919 PF07714 PF00017 PF00018 7.2 Ki ChEMBL
P53667 LIMK1 Homo sapiens Human PF00412 PF00595 PF07714 7.1 Ki ChEMBL
Q96GD4 AURKB Homo sapiens Human PF00069 7.1 Ki ChEMBL
P07949 RET Homo sapiens Human PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 7.0 Ki ChEMBL
P43405 SYK Homo sapiens Human PF07714 PF00017 7.0 Ki ChEMBL
P06239 LCK Homo sapiens Human PF07714 PF00017 PF00018 6.9 Ki ChEMBL
P49841 GSK3B Homo sapiens Human PF00069 6.9 Ki ChEMBL
P51451 BLK Homo sapiens Human PF07714 PF00017 PF00018 6.9 Ki ChEMBL
P07332 FES Homo sapiens Human PF00611 PF07714 PF00017 6.8 Ki ChEMBL
P49840 GSK3A Homo sapiens Human PF00069 6.8 Ki ChEMBL
Q9HAZ1 CLK4 Homo sapiens Human PF00069 6.7 Ki ChEMBL
P29597 TYK2 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 6.5 Ki ChEMBL
P30530 AXL Homo sapiens Human PF00041 PF13927 PF07714 6.5 Ki ChEMBL
P36888 FLT3 Homo sapiens Human PF00047 PF07714 6.5 Ki ChEMBL
Q06187 BTK Homo sapiens Human PF00779 PF00169 PF07714 PF00017 PF00018 6.5 Ki ChEMBL
P51812 RPS6KA3 Homo sapiens Human PF00069 PF00433 6.4 Ki ChEMBL
O95819 MAP4K4 Homo sapiens Human PF00780 PF00069 6.3 Ki ChEMBL
P06493 CDK1 Homo sapiens Human PF00069 6.3 Ki ChEMBL
Q08881 ITK Homo sapiens Human PF00779 PF00169 PF07714 PF00017 PF00018 6.3 Ki ChEMBL
Q00535 CDK5 Homo sapiens Human PF00069 6.2 Ki ChEMBL
P16591 FER Homo sapiens Human PF00611 PF07714 PF00017 6.1 Ki ChEMBL
P42685 FRK Homo sapiens Human PF07714 PF00017 PF00018 6.0 Ki ChEMBL
Q06418 TYRO3 Homo sapiens Human PF00041 PF07679 PF07714 6.0 Ki ChEMBL