4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)methyl)-1-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-N-(2-hydroxyethyl)benzamide

InChIKey	`YDELNSXADYPQGS-BKUYFWCQSA-N`
Compound Name	4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)methyl)-1-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-N-(2-hydroxyethyl)benzamide
Canonical SMILES	`Cn1cc(/C=C2\Oc3cccc(O)c3C2=O)c2c(-c3ccc(C(=O)NCCO)cc3)ccnc21`
Clinical Status	Clinical Multi-Target
Targets (Human+Pathogen)	15
Pfam Stratification	Cross-Family
Avg pChEMBL	7.62
Source	ChEMBL;BindingDB;TTD_MultiTarget

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
P49841	GSK3B	Homo sapiens	Human	PF00069	8.2	IC50	ChEMBL;BindingDB
P49137	MAPKAPK2	Homo sapiens	Human	PF00069	8.2	IC50	ChEMBL;BindingDB
P00519	ABL1	Homo sapiens	Human	PF08919 PF07714 PF00017 PF00018	8.0	IC50	ChEMBL;BindingDB
P18505	GABRB1	Homo sapiens	Human	PF02931 PF02932	8.0	pIC50	TTD_MultiTarget
P49840	GSK3A	Homo sapiens	Human	PF00069	8.0	IC50	ChEMBL;BindingDB
P11362	FGFR1	Homo sapiens	Human	PF07679 PF00047 PF07714	7.7	pIC50	TTD_MultiTarget
P07948	LYN	Homo sapiens	Human	PF07714 PF00017 PF00018	7.6	IC50	ChEMBL;BindingDB
P24941	CDK2	Homo sapiens	Human	PF00069	7.4	IC50	ChEMBL;BindingDB
P06493	CDK1	Homo sapiens	Human	PF00069	7.4	IC50	ChEMBL;BindingDB
Q15418	RPS6KA1	Homo sapiens	Human	PF00069 PF00433	7.3	IC50	ChEMBL;BindingDB
O15111	CHUK	Homo sapiens	Human	PF18397 PF12179 PF00069	7.3	IC50	ChEMBL;BindingDB
P17252	PRKCA	Homo sapiens	Human	PF00130 PF00168 PF00069 PF00433	7.3	IC50	ChEMBL;BindingDB
P28482	MAPK1	Homo sapiens	Human	PF00069	7.3	IC50	ChEMBL;BindingDB
P35968	KDR	Homo sapiens	Human	PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854	7.3	IC50	ChEMBL;BindingDB
Q16539	MAPK14	Homo sapiens	Human	PF00069	7.3	IC50	ChEMBL;BindingDB