1-(2,6-Dichlorophenyl)-5-(2,4-Difluorophenyl)-7-Piperazin-1-Yl-3,4-Dihydroquinazolin-2(1h)-One — MultiTargetDB

Molecule Details

InChIKey	`YAWZIQKDHQIHOS-UHFFFAOYSA-N`
Compound Name	1-(2,6-Dichlorophenyl)-5-(2,4-Difluorophenyl)-7-Piperazin-1-Yl-3,4-Dihydroquinazolin-2(1h)-One
Canonical SMILES	`O=C1NCc2c(-c3ccc(F)cc3F)cc(N3CCNCC3)cc2N1c1c(Cl)cccc1Cl`
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	2
Pfam Stratification	Cross-Family
Avg pChEMBL	7.32
Source	ChEMBL;BindingDB

2D Structure

2D structure

Activity Profile

DrugBank Annotations

DrugBank ID	DB02873
Drug Name	1-(2,6-Dichlorophenyl)-5-(2,4-Difluorophenyl)-7-Piperazin-1-Yl-3,4-Dihydroquinazolin-2(1h)-One
CAS Number	nan
Groups	experimental
ATC Codes	nan
Description	nan

Cross-references: BindingDB: 15241 CHEMBL94417 ChemSpider: 3821414 PDB: DQO PubChem:4630909 PubChem:46509163 ZINC: ZINC000012502758

Target Activities (2)

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
Q16539	MAPK14	Homo sapiens	Human	PF00069	8.6	IC50	ChEMBL;BindingDB
Q12809	KCNH2	Homo sapiens	Human	PF00027 PF00520 PF13426	6.1	Ki	ChEMBL;BindingDB

DrugBank Target Actions (1)

Target	Gene	Target Name	Action	Type
Q16539	MAPK14	Mitogen-activated protein kinase 14	binder	targets