Molecule Details
| InChIKey | YAORIDZYZDUZCM-UHFFFAOYSA-N |
|---|---|
| Compound Name | Cirazoline |
| Canonical SMILES | c1ccc(C2CC2)c(OCC2=NCCN2)c1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 5 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 6.85 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB09202 |
|---|---|
| Drug Name | Cirazoline |
| CAS Number | 59939-16-1 |
| Groups | experimental |
| ATC Codes | nan |
| Description | Cirazoline acts on a number of α adrenergic receptors. It is an agonist of α1A, partial agonist of α1B and α1D, and a nonselective antagonist of α2. It is believed that this combination of properties could make cirazoline an effective vasoconstricting agent. Cirazoline has also been shown to decreas... |
Categories: Adrenergic Agents Adrenergic Agonists Adrenergic alpha-1 Receptor Agonists Adrenergic alpha-Agonists Agents producing tachycardia Agents that produce hypertension Cardiovascular Agents Nasal Decongestants Neurotransmitter Agents Respiratory System Agents Vasoconstrictor Agents
Cross-references: BindingDB: 50027060 ChEBI: 92950 CHEMBL13852 ChemSpider: 2663 PubChem:2765 PubChem:310265110 Wikipedia: Cirazoline ZINC: ZINC000000001160
Target Activities (5)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P08908 | HTR1A | Homo sapiens | Human | PF00001 | 7.5 | Ki | ChEMBL;BindingDB |
| P08913 | ADRA2A | Homo sapiens | Human | PF00001 | 7.2 | Ki | ChEMBL;BindingDB |
| Q9Y2I1 | NISCH | Homo sapiens | Human | PF25625 PF23142 PF00787 | 7.0 | Ki | ChEMBL;BindingDB |
| P18089 | ADRA2B | Homo sapiens | Human | PF00001 | 6.3 | Ki | ChEMBL;BindingDB |
| P18825 | ADRA2C | Homo sapiens | Human | PF00001 | 6.3 | Ki | ChEMBL;BindingDB |
DrugBank Target Actions (5)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P18825 | ADRA2C | Alpha-2C adrenergic receptor | agonist | targets |
| P35348 | ADRA1A | Alpha-1A adrenergic receptor | agonist | targets |
| P08913 | ADRA2A | Alpha-2 adrenergic receptors | antagonist | targets |
| P25100 | ADRA1D | Alpha-1D adrenergic receptor | partial agonist | targets |
| P35368 | ADRA1B | Alpha-1B adrenergic receptor | partial agonist | targets |