Molecule Details
InChIKeyXZWVOUQIYLZUCJ-UHFFFAOYSA-N
Compound Name3-(5-Hydroxy-5,6,7,8-tetrahydroquinolin-2-yl)-2-oxoindoline-5-carbonitrile
Canonical SMILESN#Cc1ccc2c(c1)C(c1ccc3c(n1)CCCC3O)C(=O)N2
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)23
Pfam Stratification Cross-Family
Avg pChEMBL6.7
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (23)
Target Gene Organism Category Pfam pChEMBL Type Source
P49841 GSK3B Homo sapiens Human PF00069 7.5 Ki ChEMBL
Q9HAZ1 CLK4 Homo sapiens Human PF00069 7.5 Ki ChEMBL
P48729 CSNK1A1 Homo sapiens Human PF00069 7.4 Ki ChEMBL
P50613 CDK7 Homo sapiens Human PF00069 7.4 Ki ChEMBL
P49840 GSK3A Homo sapiens Human PF00069 7.1 Ki ChEMBL
P36888 FLT3 Homo sapiens Human PF00047 PF07714 7.0 Ki ChEMBL
Q13627 DYRK1A Homo sapiens Human PF00069 7.0 Ki ChEMBL
P07333 CSF1R Homo sapiens Human PF00047 PF25305 PF07714 6.9 Ki ChEMBL
Q9Y463 DYRK1B Homo sapiens Human PF00069 6.9 Ki ChEMBL
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 6.8 Ki ChEMBL
P51812 RPS6KA3 Homo sapiens Human PF00069 PF00433 6.8 Ki ChEMBL
P07949 RET Homo sapiens Human PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 6.6 Ki ChEMBL
O95819 MAP4K4 Homo sapiens Human PF00780 PF00069 6.5 Ki ChEMBL
P09619 PDGFRB Homo sapiens Human PF00047 PF13927 PF25305 PF07714 6.5 Ki ChEMBL
Q04912 MST1R Homo sapiens Human PF07714 PF01437 PF01403 PF01833 6.5 Ki ChEMBL
P34947 GRK5 Homo sapiens Human PF00069 PF00615 6.4 Ki ChEMBL
P49760 CLK2 Homo sapiens Human PF00069 6.4 Ki ChEMBL
P29376 LTK Homo sapiens Human PF12810 PF07714 6.3 Ki ChEMBL
Q96GD4 AURKB Homo sapiens Human PF00069 6.3 Ki ChEMBL
P50750 CDK9 Homo sapiens Human PF00069 6.2 Ki ChEMBL
P36507 MAP2K2 Homo sapiens Human PF00069 6.1 Ki ChEMBL
Q9UHD2 TBK1 Homo sapiens Human PF00069 PF18394 PF18396 6.1 Ki ChEMBL
Q02750 MAP2K1 Homo sapiens Human PF00069 6.0 Ki ChEMBL