Molecule Details
| InChIKey | XXYGTCZJJLTAGH-UHFFFAOYSA-N |
|---|---|
| Compound Name | Wnt-974 |
| Canonical SMILES | Cc1cc(-c2ncc(CC(=O)Nc3ccc(-c4cnccn4)cn3)cc2C)ccn1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 2 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 9.41 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB12561 |
|---|---|
| Drug Name | WNT-974 |
| CAS Number | 1243244-14-5 |
| Groups | investigational |
| ATC Codes | nan |
| Description | WNT974 has been used in trials studying the treatment of Metastatic Colorectal Cancer and Squamous Cell Carcinoma, Head And Neck. |
Categories: Enzyme Inhibitors
Cross-references: BindingDB: 50133870 ChEBI: 78030 CHEMBL3188386 ChemSpider: 30507712 PDB: O50 PubChem:46926973 PubChem:347828784 ZINC: ZINC000095930187
Target Activities (2)
DrugBank Target Actions (1)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| Q9H237 | PORCN | Protein-serine O-palmitoleoyltransferase porcupine | inhibitor | targets |