Molecule Details
InChIKeyXWNBGDJPEXZSQM-VZOBGQTKSA-N
Compound NameOrvepitant
Canonical SMILESCc1cc(F)ccc1[C@H]1C[C@@H](N2CCN3C(=O)CC[C@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)2
Pfam Stratification Cross-Family
Avg pChEMBL8.12
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB12427
Drug NameOrvepitant
CAS Number579475-18-6
Groups investigational
ATC Codes nan
DescriptionOrvepitant has been used in trials studying the treatment of Depressive Disorder, Depressive Disorder, Major, Post-Traumatic Stress Disorder, and Posttraumatic Stress Disorder (PTSD).
Categories: Antidepressive Agents Central Nervous System Depressants
Cross-references: BindingDB: 50442585 CHEMBL2105667 ChemSpider: 8027888 PubChem:9852175 PubChem:347828670 Wikipedia: Orvepitant ZINC: ZINC000056898864
Target Activities (2)
Target Gene Organism Category Pfam pChEMBL Type Source
P25103 TACR1 Homo sapiens Human PF00001 10.2 Ki ChEMBL;BindingDB
Q99720 SIGMAR1 Homo sapiens Human PF04622 6.0 Ki ChEMBL;BindingDB
DrugBank Target Actions (1)
Target Gene Target Name Action Type
P25103 TACR1 Substance-P receptor antagonist targets