Molecule Details
InChIKeyXUBOMFCQGDBHNK-UHFFFAOYSA-N
Canonical SMILESCOc1c(N2CCNC(C)C2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)2
Pfam Stratification Cross-Family
Avg pChEMBL6.3
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB01044
Drug NameGatifloxacin
CAS Number112811-59-3
Groups approved investigational withdrawn
ATC Codes S01AE06 J01MA16
DescriptionGatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract ...

Categories: 4-Quinolones Anti-Bacterial Agents Anti-Infective Agents Antibacterials for Systemic Use Antiinfectives for Systemic Use Compounds used in a research, industrial, or household setting Cytochrome P-450 CYP1A2 Inhibitors Cytochrome P-450 CYP1A2 Inhibitors (moderate) Cytochrome P-450 Enzyme Inhibitors Enzyme Inhibitors Fluoroquinolones Heterocyclic Compounds, Fused-Ring Hypoglycemia-Associated Agents Ophthalmic Solutions Ophthalmologicals Pharmaceutical Preparations Pharmaceutical Solutions Potential QTc-Prolonging Agents QTc Prolonging Agents Quinolines Quinolone Antimicrobial Quinolones Sensory Organs Solutions Topoisomerase II Inhibitors Topoisomerase Inhibitors
Cross-references: BindingDB: 50117914 ChEBI: 5280 CHEMBL31 ChemSpider: 5186 Drugs Product Database (DPD): 12056 C07661 D08011 PharmGKB: PA449738 PubChem:5379 PubChem:46506159 RxCUI: 1546025 Therapeutic Targets Database: DAP001387 Wikipedia: Gatifloxacin
Target Activities (2)
Target Gene Organism Category Pfam pChEMBL Type Source
P0AES4 gyrA Escherichia coli (strain K12) Pathogen PF03989 PF00521 6.3 IC50 ChEMBL;BindingDB
P0AES6 gyrB Escherichia coli (strain K12) Pathogen PF00204 PF00986 PF21249 PF18053 PF02518 PF01751 6.3 IC50 ChEMBL
DrugBank Target Actions (8)
Target Gene Target Name Action Type
P02768 ALB Albumin other/unknown carriers
P05177 CYP1A2 Cytochrome P450 1A2 inhibitor enzymes
P0A0K8 gyrB DNA gyrase subunit B inhibitor targets
P0A4L9 gyrB DNA gyrase subunit B inhibitor targets
P20831 gyrA DNA gyrase subunit A inhibitor targets
P72524 P72524 DNA gyrase subunit A inhibitor targets
P72525 P72525 DNA topoisomerase 4 subunit A inhibitor targets
Q59961 Q59961 DNA topoisomerase 4 subunit B inhibitor targets