Molecule Details
InChIKeyXTVULKIROSNNTG-UHFFFAOYSA-N
Compound Name2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(4-(hydroxymethyl)phenyl)thiazole-4-carboxylic acid
Canonical SMILESO=C(Nc1nc2ccccc2s1)c1cccc2c1CN(c1nc(C(=O)O)c(-c3ccc(CO)cc3)s1)CC2
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)29
Pfam Stratification Cross-Family
Avg pChEMBL6.19
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (29)
Target Gene Organism Category Pfam pChEMBL Type Source
O14965 AURKA Homo sapiens Human PF00069 6.7 Ki ChEMBL
P53667 LIMK1 Homo sapiens Human PF00412 PF00595 PF07714 6.7 Ki ChEMBL
P08581 MET Homo sapiens Human PF07714 PF01437 PF01403 PF01833 6.6 Ki ChEMBL
Q7L7X3 TAOK1 Homo sapiens Human PF00069 6.5 Ki ChEMBL
P50750 CDK9 Homo sapiens Human PF00069 6.4 Ki ChEMBL
P36888 FLT3 Homo sapiens Human PF00047 PF07714 6.3 Ki ChEMBL
Q06418 TYRO3 Homo sapiens Human PF00041 PF07679 PF07714 6.3 Ki ChEMBL
Q8IU85 CAMK1D Homo sapiens Human PF00069 6.3 Ki ChEMBL
P36507 MAP2K2 Homo sapiens Human PF00069 6.2 Ki ChEMBL
P49336 CDK8 Homo sapiens Human PF00069 6.2 Ki ChEMBL
P49840 GSK3A Homo sapiens Human PF00069 6.2 Ki ChEMBL
P49841 GSK3B Homo sapiens Human PF00069 6.2 Ki ChEMBL
P50613 CDK7 Homo sapiens Human PF00069 6.2 Ki ChEMBL
Q13627 DYRK1A Homo sapiens Human PF00069 6.2 Ki ChEMBL
Q5S007 LRRK2 Homo sapiens Human PF23745 PF23744 PF23748 PF16095 PF25497 PF13855 PF00069 PF08477 6.2 Ki ChEMBL
Q9HAZ1 CLK4 Homo sapiens Human PF00069 6.2 Ki ChEMBL
Q9Y463 DYRK1B Homo sapiens Human PF00069 6.1 Ki ChEMBL
O14757 CHEK1 Homo sapiens Human PF00069 6.0 Ki ChEMBL
P04629 NTRK1 Homo sapiens Human PF13855 PF16920 PF07714 PF18613 6.0 Ki ChEMBL
P09619 PDGFRB Homo sapiens Human PF00047 PF13927 PF25305 PF07714 6.0 Ki ChEMBL
P17612 PRKACA Homo sapiens Human PF00069 6.0 Ki ChEMBL
P29376 LTK Homo sapiens Human PF12810 PF07714 6.0 Ki ChEMBL
P34947 GRK5 Homo sapiens Human PF00069 PF00615 6.0 Ki ChEMBL
P48729 CSNK1A1 Homo sapiens Human PF00069 6.0 Ki ChEMBL
Q02750 MAP2K1 Homo sapiens Human PF00069 6.0 Ki ChEMBL
Q13464 ROCK1 Homo sapiens Human PF25346 PF00069 PF08912 6.0 Ki ChEMBL
Q16539 MAPK14 Homo sapiens Human PF00069 6.0 Ki ChEMBL
Q96GD4 AURKB Homo sapiens Human PF00069 6.0 Ki ChEMBL
Q9UQM7 CAMK2A Homo sapiens Human PF08332 PF00069 6.0 Ki ChEMBL