InChIKey	XTULMSXFIHGYFS-VLSRWLAYSA-N
Compound Name	Fluticasone Furoate
Canonical SMILES	C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(OC(=O)c1ccco1)C(=O)SCF
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	3
Pfam Stratification	Homologous
Avg pChEMBL	7.92
Source	ChEMBL;BindingDB

DrugBank ID	DB08906
Drug Name	Fluticasone furoate
CAS Number	397864-44-7
Groups	approved investigational
ATC Codes	R03AL08 R01AD12 R03AK10 R03BA09
Description	Fluticasone furoate is a synthetic glucocorticoid available as an inhaler and nasal spray for various inflammatory indications[FDA Label][F4364]. Fluticasone furoate was first approved in 2007[L5965].

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Categories: Adrenal Cortex Hormones Agents to Treat Airway Disease Androstanes Androstenes Corticosteroids Cytochrome P-450 CYP2C8 Inhibitors Cytochrome P-450 CYP2C8 Inhibitors (strong) Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (strength unknown) Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Inducers Cytochrome P-450 CYP3A5 Inducers (strength unknown) Cytochrome P-450 CYP3A5 Inhibitors Cytochrome P-450 CYP3A5 Inhibitors (strength unknown) Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 CYP3A7 Substrates Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Drugs for Obstructive Airway Diseases Fused-Ring Compounds Glucocorticoids Hyperglycemia-Associated Agents Immunosuppressive Agents Nasal Preparations OATP1B1/SLCO1B1 Inhibitors P-glycoprotein inducers P-glycoprotein substrates Steroids Thyroxine-binding globulin inhibitors

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Cross-references: BindingDB: 50354851 ChEBI: 74899 CHEMBL1676 ChemSpider: 8030195 Drugs Product Database (DPD): 20155 D06315 PDB: GW6 PubChem:9854489 PubChem:175427145 RxCUI: 705022 Wikipedia: Fluticasone_furoate ZINC: ZINC000003992105