InChIKey	XTNGUQKDFGDXSJ-ZXGKGEBGSA-N
Compound Name	Canagliflozin
Canonical SMILES	Cc1ccc([C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1Cc1ccc(-c2ccc(F)cc2)s1
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	3
Pfam Stratification	Cross-Family
Avg pChEMBL	7.03
Source	ChEMBL;BindingDB

DrugBank ID	DB08907
Drug Name	Canagliflozin
CAS Number	842133-18-0
Groups	approved investigational
ATC Codes	A10BD16 A10BK02
Description	Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and late...

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Categories: Agents causing hyperkalemia Alimentary Tract and Metabolism Blood Glucose Lowering Agents Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Substrates Diuretics Drugs Used in Diabetes Drugs that are Mainly Renally Excreted Glucosides Hypotensive Agents Oral Hypoglycemics P-glycoprotein inhibitors P-glycoprotein substrates Sodium-glucose Cotransporter 2 (SGLT2) Inhibitors Sulfur Compounds Thiophenes UGT1A9 Substrates

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Cross-references: BindingDB: 50386885 ChEBI: 73274 CHEMBL2048484 ChemSpider: 26333259 Drugs Product Database (DPD): 22295 D09592 PDB: L3R PubChem:24812758 PubChem:175427146 RxCUI: 1373458 Wikipedia: Canagliflozin ZINC: ZINC000043207238