6-(3-aminophenyl)-N-tert-butyl-2-(trifluoromethyl)quinazolin-4-amine — MultiTargetDB

Molecule Details

InChIKey	`XQKJVNGGVLHNLA-UHFFFAOYSA-N`
Compound Name	6-(3-aminophenyl)-N-tert-butyl-2-(trifluoromethyl)quinazolin-4-amine
Canonical SMILES	`CC(C)(C)Nc1nc(C(F)(F)F)nc2ccc(-c3cccc(N)c3)cc12`
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	3
Pfam Stratification	Cross-Family
Avg pChEMBL	6.22
Source	ChEMBL;BindingDB

2D Structure

2D structure

Activity Profile

DrugBank Annotations

DrugBank ID	DB07612
Drug Name	6-(3-AMINOPHENYL)-N-(TERT-BUTYL)-2-(TRIFLUOROMETHYL)QUINAZOLIN-4-AMINE
CAS Number	nan
Groups	experimental
ATC Codes	nan
Description	nan

Cross-references: BindingDB: 7001 CHEMBL278894 ChemSpider: 4450261 PDB: D23 PubChem:5288016 PubChem:99444083 ZINC: ZINC000014945742

Target Activities (3)

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
O96020	CCNE2	Homo sapiens	Human	PF02984 PF00134	6.2	IC50	ChEMBL
P24864	CCNE1	Homo sapiens	Human	PF02984 PF00134	6.2	IC50	ChEMBL
P24941	CDK2	Homo sapiens	Human	PF00069	6.2	IC50	ChEMBL;BindingDB

DrugBank Target Actions (1)

Target	Gene	Target Name	Action	Type
P24941	CDK2	Cyclin-dependent kinase 2	binder	targets