Molecule Details
| InChIKey | XPLJEFSRINKZLC-ATVHPVEESA-N |
|---|---|
| Compound Name | SU-11652 |
| Canonical SMILES | CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(Cl)cc32)c1C |
| Clinical Status | Clinical Multi-Target |
| Targets (Human+Pathogen) | 5 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 7.48 |
| Source | ChEMBL;BindingDB;TTD_MultiTarget |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB08009 |
|---|---|
| Drug Name | SU-11652 |
| CAS Number | 326914-10-7 |
| Groups | experimental |
| ATC Codes | nan |
| Description | SU-11652 is a tyrosine kinase inhibitor. |
Categories: Heterocyclic Compounds, Fused-Ring
Cross-references: BindingDB: 4815 ChEBI: 132084 CHEMBL13485 ChemSpider: 4486265 PDB: J60 PubChem:5329103 PubChem:99444480 ZINC: ZINC000003989259
Target Activities (5)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P09619 | PDGFRB | Homo sapiens | Human | PF00047 PF13927 PF25305 PF07714 | 8.5 | IC50 | ChEMBL;BindingDB |
| P10721 | KIT | Homo sapiens | Human | PF00047 PF07714 | 8.0 | IC50 | ChEMBL;BindingDB |
| P35968 | KDR | Homo sapiens | Human | PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 | 7.6 | IC50 | ChEMBL;BindingDB |
| P11362 | FGFR1 | Homo sapiens | Human | PF07679 PF00047 PF07714 | 7.2 | pIC50 | TTD_MultiTarget |
| Q14680 | MELK | Homo sapiens | Human | PF02149 PF00069 PF21594 | 6.1 | IC50 | ChEMBL;BindingDB |
DrugBank Target Actions (5)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| Q96NX5 | CAMK1G | Calcium/calmodulin-dependent protein kinase type 1G | binder | targets |
| P09619 | PDGFRB | Platelet-derived growth factor receptor beta | inhibitor | targets |
| P16234 | PDGFRA | Platelet-derived growth factor receptor alpha | inhibitor | targets |
| P17948 | FLT1 | Vascular endothelial growth factor receptor 1 | inhibitor | targets |
| P35968 | KDR | Vascular endothelial growth factor receptor 2 | inhibitor | targets |