InChIKey	XMXHEBAFVSFQEX-UHFFFAOYSA-N
Compound Name	Iloperidone
Canonical SMILES	COc1cc(C(C)=O)ccc1OCCCN1CCC(c2noc3cc(F)ccc23)CC1
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	17
Pfam Stratification	Cross-Family
Avg pChEMBL	7.69
Source	BindingDB;ChEMBL

DrugBank ID	DB04946
Drug Name	Iloperidone
CAS Number	133454-47-4
Groups	approved investigational
ATC Codes	N05AX14
Description	Iloperidone is a benzisoxazole [A263557] and an atypical antipsychotic agent that was first approved by the FDA on May 6, 2009.[A3024] It is considered to be a second-generation antipsychotic drug [A263552] with multiple receptor binding profile, although it shows high affinity towards 5-HT<sub>2A</...

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Categories: Adrenergic Antagonists Adrenergic alpha-1 Receptor Antagonists Adrenergic alpha-Antagonists Agents that produce hypertension Antidepressive Agents Antipsychotic Agents Antipsychotic Agents (Second Generation [Atypical]) Central Nervous System Agents Central Nervous System Depressants Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Substrates Dopamine Antagonists Dopamine D2 Receptor Antagonists Highest Risk QTc-Prolonging Agents Histamine Antagonists Histamine H1 Antagonists Hyperglycemia-Associated Agents Nervous System Neurotoxic agents Psycholeptics Psychotropic Drugs QTc Prolonging Agents Schizophrenia Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome Serotonin 5-HT1 Receptor Antagonists Serotonin 5-HT1A Receptor Antagonists Serotonin 5-HT2 Receptor Antagonists Serotonin 5-HT2A Receptor Antagonists Serotonin 5-HT2C Receptor Antagonists Serotonin Agents Serotonin Receptor Antagonists Tranquilizing Agents

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Cross-references: BindingDB: 50034043 ChEBI: 65173 CHEMBL14376 ChemSpider: 64459 D02666 PharmGKB: PA161199368 PubChem:71360 PubChem:175426913 RxCUI: 73178 Wikipedia: Iloperidone ZINC: ZINC000001548097