Molecule Details
InChIKeyXMFUGSRATNLPRM-UHFFFAOYSA-N
Compound NameN-(2-aminoethyl)-5-(dimethylamino)-N-(5-isoquinolin-6-yl-3-pyridinyl)naphthalene-1-sulfonamide
Canonical SMILESCN(C)c1cccc2c(S(=O)(=O)N(CCN)c3cncc(-c4ccc5cnccc5c4)c3)cccc12
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)19
Pfam Stratification Homologous
Avg pChEMBL6.78
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (19)
Target Gene Organism Category Pfam pChEMBL Type Source
O75116 ROCK2 Homo sapiens Human PF25346 PF00069 PF08912 8.3 Ki ChEMBL
P51817 PRKX Homo sapiens Human PF00069 7.6 Ki ChEMBL
Q13464 ROCK1 Homo sapiens Human PF25346 PF00069 PF08912 7.4 Ki ChEMBL
P17612 PRKACA Homo sapiens Human PF00069 7.3 Ki ChEMBL
Q13976 PRKG1 Homo sapiens Human PF00027 PF16808 PF00069 7.1 Ki ChEMBL
Q9HAZ1 CLK4 Homo sapiens Human PF00069 7.0 Ki ChEMBL
P11309 PIM1 Homo sapiens Human PF00069 6.9 Ki ChEMBL
Q13237 PRKG2 Homo sapiens Human PF00027 PF00069 6.9 Ki ChEMBL
O43781 DYRK3 Homo sapiens Human PF00069 6.7 Ki ChEMBL
Q86V86 PIM3 Homo sapiens Human PF00069 6.6 Ki ChEMBL
O75582 RPS6KA5 Homo sapiens Human PF00069 PF00433 6.5 Ki ChEMBL
P23443 RPS6KB1 Homo sapiens Human PF00069 PF00433 6.5 Ki ChEMBL
Q05655 PRKCD Homo sapiens Human PF00130 PF21494 PF00069 PF00433 6.5 Ki ChEMBL
Q16513 PKN2 Homo sapiens Human PF02185 PF00069 PF00433 6.5 Ki ChEMBL
Q13627 DYRK1A Homo sapiens Human PF00069 6.4 Ki ChEMBL
Q14680 MELK Homo sapiens Human PF02149 PF00069 PF21594 6.4 Ki ChEMBL
O96017 CHEK2 Homo sapiens Human PF00498 PF00069 6.3 Ki ChEMBL
O43293 DAPK3 Homo sapiens Human PF00069 6.0 Ki ChEMBL
Q5VT25 CDC42BPA Homo sapiens Human PF00130 PF00780 PF08826 PF15796 PF25346 PF00069 PF00433 6.0 Ki ChEMBL