Molecule Details
InChIKeyXLIBABIFOBYHSV-UHFFFAOYSA-N
Compound NameMak-683
Canonical SMILESCc1ncccc1-c1cnc(NCc2c(F)ccc3c2CCO3)n2cnnc12
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)3
Pfam Stratification Cross-Family
Avg pChEMBL8.24
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB19205
Drug NameMAK-683
CAS Number1951408-58-4
Groups investigational
ATC Codes nan
Descriptionnan
Cross-references: BindingDB: 291687 CHEMBL4755618 ChemSpider: 67886340
Target Activities (3)
Target Gene Organism Category Pfam pChEMBL Type Source
O75530 EED Homo sapiens Human PF00400 8.3 IC50 ChEMBL;BindingDB
Q15022 SUZ12 Homo sapiens Human PF09733 PF23320 8.2 IC50 ChEMBL
Q15910 EZH2 Homo sapiens Human PF21358 PF11616 PF18118 PF18264 PF00856 8.2 IC50 ChEMBL;BindingDB
DrugBank Target Actions (1)
Target Gene Target Name Action Type
O75530 EED Polycomb protein EED inhibitor targets