Molecule Details
InChIKeyXKZQZMSAWVDRSP-UHFFFAOYSA-N
Compound NameN-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl)imidazo[2,1-b]thiazol-6-yl)phenyl)-2-phenylacetamide
Canonical SMILESO=C(Cc1ccccc1)Nc1cccc(-c2nc3sccn3c2-c2ccnc(Nc3cccc(N4CCOCC4)c3)n2)c1
Clinical Status Clinical Multi-Target
Targets (Human+Pathogen)39
Pfam Stratification Cross-Family
Avg pChEMBL6.82
SourceChEMBL;BindingDB;TTD_MultiTarget
2D Structure
2D structure
Activity Profile
Target Activities (39)
Target Gene Organism Category Pfam pChEMBL Type Source
Q9Y4K4 MAP4K5 Homo sapiens Human PF00780 PF00069 8.3 Ki ChEMBL
Q15303 ERBB4 Homo sapiens Human PF00757 PF14843 PF07714 PF01030 PF21314 7.8 IC50 ChEMBL;BindingDB
P07949 RET Homo sapiens Human PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 7.7 Ki ChEMBL
P45984 MAPK9 Homo sapiens Human PF00069 7.6 Ki ChEMBL
P07948 LYN Homo sapiens Human PF07714 PF00017 PF00018 7.6 IC50 ChEMBL;BindingDB
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 7.5 IC50 ChEMBL;BindingDB
P42685 FRK Homo sapiens Human PF07714 PF00017 PF00018 7.5 Ki ChEMBL
O95819 MAP4K4 Homo sapiens Human PF00780 PF00069 7.3 Ki ChEMBL
O14965 AURKA Homo sapiens Human PF00069 7.2 IC50 ChEMBL;BindingDB
O75716 STK16 Homo sapiens Human PF00069 7.2 pIC50 TTD_MultiTarget
P35916 FLT4 Homo sapiens Human PF07679 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 7.2 IC50 ChEMBL;BindingDB
P06239 LCK Homo sapiens Human PF07714 PF00017 PF00018 7.2 IC50 ChEMBL;BindingDB
P04626 ERBB2 Homo sapiens Human PF00757 PF14843 PF07714 PF01030 PF21314 7.1 pIC50 TTD_MultiTarget
P06213 INSR Homo sapiens Human PF00757 PF17870 PF07714 PF01030 7.1 IC50 ChEMBL;BindingDB
Q12851 MAP4K2 Homo sapiens Human PF00780 PF00069 7.1 Ki ChEMBL
Q9H2G2 SLK Homo sapiens Human PF00069 PF12474 7.1 Ki ChEMBL
P06241 FYN Homo sapiens Human PF07714 PF00017 PF00018 7.0 Ki ChEMBL
P06729 CD2 Homo sapiens Human PF05790 PF07686 6.8 pIC50 TTD_MultiTarget
P08069 IGF1R Homo sapiens Human PF00757 PF07714 PF01030 6.8 IC50 ChEMBL;BindingDB
P00533 EGFR Homo sapiens Human PF00757 PF14843 PF07714 PF01030 PF21314 6.7 IC50 ChEMBL;BindingDB
Q9NYL2 MAP3K20 Homo sapiens Human PF07714 PF07647 6.7 Ki ChEMBL
P45983 MAPK8 Homo sapiens Human PF00069 6.6 Ki ChEMBL
Q7L7X3 TAOK1 Homo sapiens Human PF00069 6.6 Ki ChEMBL
P12931 SRC Homo sapiens Human PF07714 PF00017 PF00018 6.5 IC50 ChEMBL;BindingDB
P51955 NEK2 Homo sapiens Human PF00069 6.5 IC50 ChEMBL;BindingDB
P51451 BLK Homo sapiens Human PF07714 PF00017 PF00018 6.5 IC50 ChEMBL;BindingDB
Q8NE63 HIPK4 Homo sapiens Human PF00069 6.5 Ki ChEMBL
P29317 EPHA2 Homo sapiens Human PF14575 PF25599 PF01404 PF00041 PF07714 PF00536 6.4 IC50 ChEMBL;BindingDB
P11362 FGFR1 Homo sapiens Human PF07679 PF00047 PF07714 6.4 Ki ChEMBL
Q05397 PTK2 Homo sapiens Human PF21477 PF00373 PF18038 PF03623 PF07714 6.3 Ki ChEMBL
Q13153 PAK1 Homo sapiens Human PF00786 PF00069 6.3 IC50 ChEMBL;BindingDB
P43405 SYK Homo sapiens Human PF07714 PF00017 6.2 Ki ChEMBL
Q13188 STK3 Homo sapiens Human PF11629 PF00069 6.2 IC50 ChEMBL;BindingDB
Q96GD4 AURKB Homo sapiens Human PF00069 6.2 IC50 ChEMBL;BindingDB
P48730 CSNK1D Homo sapiens Human PF00069 6.1 IC50 ChEMBL;BindingDB
P49841 GSK3B Homo sapiens Human PF00069 6.1 Ki ChEMBL
Q9H3Y6 SRMS Homo sapiens Human PF07714 PF00017 6.1 Ki ChEMBL
P07333 CSF1R Homo sapiens Human PF00047 PF25305 PF07714 6.0 Ki ChEMBL
P29597 TYK2 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 6.0 Ki ChEMBL