Molecule Details
InChIKeyXJJYJNMNYDNXNO-UHFFFAOYSA-N
Compound Name2-(2-(2-Fluorophenyl)pyridin-4-YL)-1,5,6,7-tetrahydro-4H-pyrrolo(3,2-C)pyridin-4-one
Canonical SMILESO=C1NCCc2[nH]c(-c3ccnc(-c4ccccc4F)c3)cc21
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)23
Pfam Stratification Cross-Family
Avg pChEMBL6.49
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB07728
Drug Name2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE
CAS Numbernan
Groups experimental
ATC Codes nan
Descriptionnan

Cross-references: BindingDB: 30192 CHEMBL226471 ChemSpider: 10164613 PDB: F10 PubChem:11992146 PubChem:99444199 ZINC: ZINC000016052794
Target Activities (23)
Target Gene Organism Category Pfam pChEMBL Type Source
Q13627 DYRK1A Homo sapiens Human PF00069 8.0 Ki ChEMBL
O95819 MAP4K4 Homo sapiens Human PF00780 PF00069 7.6 Ki ChEMBL
P45983 MAPK8 Homo sapiens Human PF00069 6.8 Ki ChEMBL
P78368 CSNK1G2 Homo sapiens Human PF12605 PF00069 6.8 Ki ChEMBL
O43781 DYRK3 Homo sapiens Human PF00069 6.7 Ki ChEMBL
Q8IW41 MAPKAPK5 Homo sapiens Human PF00069 6.7 IC50 ChEMBL;BindingDB
Q8N4C8 MINK1 Homo sapiens Human PF00780 PF00069 6.6 Ki ChEMBL
Q9BZL6 PRKD2 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 6.6 Ki ChEMBL
P49137 MAPKAPK2 Homo sapiens Human PF00069 6.6 IC50 ChEMBL;BindingDB
O94806 PRKD3 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 6.5 Ki ChEMBL
P45984 MAPK9 Homo sapiens Human PF00069 6.5 Ki ChEMBL
Q9HAZ1 CLK4 Homo sapiens Human PF00069 6.5 Ki ChEMBL
P52333 JAK3 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 6.3 IC50 ChEMBL;BindingDB
O43293 DAPK3 Homo sapiens Human PF00069 6.2 Ki ChEMBL
O96017 CHEK2 Homo sapiens Human PF00498 PF00069 6.2 Ki ChEMBL
P00533 EGFR Homo sapiens Human PF00757 PF14843 PF07714 PF01030 PF21314 6.2 Ki ChEMBL
Q9HCP0 CSNK1G1 Homo sapiens Human PF12605 PF00069 6.2 Ki ChEMBL
Q9Y4K4 MAP4K5 Homo sapiens Human PF00780 PF00069 6.2 Ki ChEMBL
O00444 PLK4 Homo sapiens Human PF00069 PF18190 PF18409 6.1 Ki ChEMBL
P11309 PIM1 Homo sapiens Human PF00069 6.1 Ki ChEMBL
P23443 RPS6KB1 Homo sapiens Human PF00069 PF00433 6.0 Ki ChEMBL
P48730 CSNK1D Homo sapiens Human PF00069 6.0 Ki ChEMBL
Q12851 MAP4K2 Homo sapiens Human PF00780 PF00069 6.0 Ki ChEMBL
DrugBank Target Actions (2)
Target Gene Target Name Action Type
P49137 MAPKAPK2 MAP kinase-activated protein kinase 2 binder targets
Q16644 MAPKAPK3 MAP kinase-activated protein kinase 3 binder targets