Molecule Details
| InChIKey | XHOLNRLADUSQLD-UHFFFAOYSA-N |
|---|---|
| Canonical SMILES | COc1ccc(NC(=O)c2ccc(C(=N)N(C)C)cc2)c(C(=O)Nc2ccc(Cl)cn2)c1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 2 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 8.28 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB12364 |
|---|---|
| Drug Name | Betrixaban |
| CAS Number | 330942-05-7 |
| Groups | approved |
| ATC Codes | B01AF04 |
| Description | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa [A7708]. It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity [A27286]. Betrixaban, now de... |
Categories: Acids, Carbocyclic Amides Anticoagulants Antithrombins Benzene Derivatives Benzoates Blood and Blood Forming Organs Direct factor Xa inhibitors Enzyme Inhibitors Factor Xa Inhibitors Hematologic Agents P-glycoprotein substrates Protease Inhibitors Serine Protease Inhibitors
Cross-references: BindingDB: 50249298 ChEBI: 140421 CHEMBL512351 ChemSpider: 18981107 PubChem:10275777 PubChem:347828616 RxCUI: 1927851 Wikipedia: Betrixaban ZINC: ZINC000030691754