InChIKey	XGALLCVXEZPNRQ-UHFFFAOYSA-N
Compound Name	Gefitinib
Canonical SMILES	COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1
Clinical Status	Clinical Multi-Target
Targets (Human+Pathogen)	39
Pfam Stratification	Cross-Family
Avg pChEMBL	6.54
Source	BindingDB;ChEMBL;TTD_MultiTarget

DrugBank ID	DB00317
Drug Name	Gefitinib
CAS Number	184475-35-2
Groups	approved investigational
ATC Codes	L01EB01
Description	Gefitinib (originally coded ZD1839) is a drug used in the treatment of certain types of cancer. Acting in a similar manner to erlotinib (marketed as Tarceva), gefitinib selectively targets the mutant proteins in malignant cells. It is marketed by AstraZeneca under the trade name Iressa.

---

Categories: Antineoplastic Agents Antineoplastic and Immunomodulating Agents BCRP/ABCG2 Inhibitors BCRP/ABCG2 Substrates Cytochrome P-450 CYP1A1 Substrates Cytochrome P-450 CYP2C19 Inhibitors Cytochrome P-450 CYP2C19 inhibitors (strength unknown) Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (strength unknown) Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (weak) Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Enzyme Inhibitors Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors Heterocyclic Compounds, Fused-Ring Kinase Inhibitor P-glycoprotein inhibitors P-glycoprotein substrates Protein Kinase Inhibitors Quinazolines Tyrosine Kinase Inhibitors

---

Cross-references: BindingDB: 5447 ChEBI: 49668 CHEMBL939 ChemSpider: 110217 Drugs Product Database (DPD): 13090 D01977 PDB: IRE PharmGKB: PA131301952 PubChem:123631 PubChem:46508649 RxCUI: 328134 Therapeutic Targets Database: DAP000657 Wikipedia: Gefitinib ZINC: ZINC000019632614