Molecule Details
InChIKeyXFYDIVBRZNQMJC-UHFFFAOYSA-N
Compound NameTizanidine
Canonical SMILESClc1ccc2nsnc2c1NC1=NCCN1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)2
Pfam Stratification Cross-Family
Avg pChEMBL7.38
SourceBindingDB;ChEMBL
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB00697
Drug NameTizanidine
CAS Number51322-75-9
Groups approved investigational
ATC Codes M03BX02
DescriptionTizanidine is a fast-acting drug used for the management of muscle spasm, which may result from the effects of multiple sclerosis, stroke, an acquired brain injury, or a spinal cord injury [T574]. It may also be caused by musculoskeletal injury [A177583]. Regardless of the cause, muscle spasticity c...

Categories: Adrenergic Agents Adrenergic Agonists Adrenergic alpha-2 Receptor Agonists Adrenergic alpha-Agonists Agents producing tachycardia Analgesics Anticonvulsants Autonomic Agents Bradycardia-Causing Agents Central Nervous System Agents Central Nervous System Depressants Central alpha-2 Adrenergic Agonist Cytochrome P-450 CYP1A2 Substrates Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index Cytochrome P-450 Substrates Hypotensive Agents Imidazoles Imidazolines Muscle Relaxants Muscle Relaxants, Centrally Acting Agents Musculo-Skeletal System Narrow Therapeutic Index Drugs Neuromuscular Agents Neurotransmitter Agents Potential QTc-Prolonging Agents QTc Prolonging Agents Sensory System Agents
Cross-references: BindingDB: 50240671 ChEBI: 63629 CHEMBL1079 ChemSpider: 5287 Drugs Product Database (DPD): 11821 C07452 PharmGKB: PA451701 PubChem:5487 PubChem:46505373 RxCUI: 57258 Therapeutic Targets Database: DAP000234 Wikipedia: Tizanidine ZINC: ZINC000019702309
Target Activities (2)
Target Gene Organism Category Pfam pChEMBL Type Source
Q9Y2I1 NISCH Homo sapiens Human PF25625 PF23142 PF00787 7.5 Ki ChEMBL;BindingDB
P08913 ADRA2A Homo sapiens Human PF00001 7.2 Ki BindingDB
DrugBank Target Actions (4)
Target Gene Target Name Action Type
P05177 CYP1A2 Cytochrome P450 1A2 substrate enzymes
P08913 ADRA2A Alpha-2 adrenergic receptors agonist targets
P35348 ADRA1A Alpha-1 adrenergic receptors agonist targets
Q9Y2I1 NISCH Nischarin agonist targets