Molecule Details
InChIKeyXFWUTMHVDGPWLH-UHFFFAOYSA-N
Compound NameN-benzyl-6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine
Canonical SMILESClc1cc(-c2c[nH]c3ncccc23)cc(NCc2ccccc2)n1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)75
Pfam Stratification Cross-Family
Avg pChEMBL7.1
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (75)
Target Gene Organism Category Pfam pChEMBL Type Source
Q16513 PKN2 Homo sapiens Human PF02185 PF00069 PF00433 8.6 Ki ChEMBL
P49760 CLK2 Homo sapiens Human PF00069 8.4 Ki ChEMBL
Q13131 PRKAA1 Homo sapiens Human PF16579 PF21147 PF00069 8.4 Ki ChEMBL
Q13627 DYRK1A Homo sapiens Human PF00069 8.4 Ki ChEMBL
Q00535 CDK5 Homo sapiens Human PF00069 8.3 Ki ChEMBL
P78368 CSNK1G2 Homo sapiens Human PF12605 PF00069 8.2 Ki ChEMBL
P52333 JAK3 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 8.1 Ki ChEMBL
Q05655 PRKCD Homo sapiens Human PF00130 PF21494 PF00069 PF00433 8.1 Ki ChEMBL
O75116 ROCK2 Homo sapiens Human PF25346 PF00069 PF08912 8.0 Ki ChEMBL
P06241 FYN Homo sapiens Human PF07714 PF00017 PF00018 8.0 Ki ChEMBL
P49841 GSK3B Homo sapiens Human PF00069 8.0 Ki ChEMBL
Q9H2G2 SLK Homo sapiens Human PF00069 PF12474 8.0 Ki ChEMBL
O75582 RPS6KA5 Homo sapiens Human PF00069 PF00433 7.8 Ki ChEMBL
Q5VT25 CDC42BPA Homo sapiens Human PF00130 PF00780 PF08826 PF15796 PF25346 PF00069 PF00433 7.8 Ki ChEMBL
Q9HCP0 CSNK1G1 Homo sapiens Human PF12605 PF00069 7.8 Ki ChEMBL
P17612 PRKACA Homo sapiens Human PF00069 7.7 Ki ChEMBL
P24941 CDK2 Homo sapiens Human PF00069 7.7 Ki ChEMBL
Q9Y6M4 CSNK1G3 Homo sapiens Human PF12605 PF00069 7.7 Ki ChEMBL
P06493 CDK1 Homo sapiens Human PF00069 7.6 Ki ChEMBL
P50613 CDK7 Homo sapiens Human PF00069 7.6 Ki ChEMBL
Q13464 ROCK1 Homo sapiens Human PF25346 PF00069 PF08912 7.6 Ki ChEMBL
O60674 JAK2 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 7.5 Ki ChEMBL
Q16288 NTRK3 Homo sapiens Human PF07679 PF00047 PF13855 PF16920 PF01462 PF07714 7.5 Ki ChEMBL
P36888 FLT3 Homo sapiens Human PF00047 PF07714 7.4 Ki ChEMBL
P51451 BLK Homo sapiens Human PF07714 PF00017 PF00018 7.3 Ki ChEMBL
P51617 IRAK1 Homo sapiens Human PF00531 PF00069 7.3 Ki ChEMBL
O43293 DAPK3 Homo sapiens Human PF00069 7.2 Ki ChEMBL
O43781 DYRK3 Homo sapiens Human PF00069 7.2 Ki ChEMBL
P06239 LCK Homo sapiens Human PF07714 PF00017 PF00018 7.2 Ki ChEMBL
P48730 CSNK1D Homo sapiens Human PF00069 7.2 Ki ChEMBL
Q9H2X6 HIPK2 Homo sapiens Human PF00069 7.2 Ki ChEMBL
P12931 SRC Homo sapiens Human PF07714 PF00017 PF00018 7.1 Ki ChEMBL
P23443 RPS6KB1 Homo sapiens Human PF00069 PF00433 7.1 Ki ChEMBL
P42685 FRK Homo sapiens Human PF07714 PF00017 PF00018 7.1 Ki ChEMBL
P51817 PRKX Homo sapiens Human PF00069 7.1 Ki ChEMBL
Q13557 CAMK2D Homo sapiens Human PF08332 PF00069 7.1 Ki ChEMBL
P50750 CDK9 Homo sapiens Human PF00069 7.0 Ki ChEMBL
Q13555 CAMK2G Homo sapiens Human PF08332 PF00069 7.0 Ki ChEMBL
Q9NWZ3 IRAK4 Homo sapiens Human PF07714 7.0 Ki ChEMBL
P16591 FER Homo sapiens Human PF00611 PF07714 PF00017 6.9 Ki ChEMBL
O94806 PRKD3 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 6.8 Ki ChEMBL
P04629 NTRK1 Homo sapiens Human PF13855 PF16920 PF07714 PF18613 6.8 Ki ChEMBL
P07333 CSF1R Homo sapiens Human PF00047 PF25305 PF07714 6.8 Ki ChEMBL
P11309 PIM1 Homo sapiens Human PF00069 6.8 Ki ChEMBL
P27448 MARK3 Homo sapiens Human PF02149 PF00069 PF00627 6.8 Ki ChEMBL
Q9HBH9 MKNK2 Homo sapiens Human PF00069 6.8 Ki ChEMBL
Q9NYL2 MAP3K20 Homo sapiens Human PF07714 PF07647 6.8 Ki ChEMBL
Q9UEE5 STK17A Homo sapiens Human PF00069 6.8 Ki ChEMBL
P00533 EGFR Homo sapiens Human PF00757 PF14843 PF07714 PF01030 PF21314 6.7 Ki ChEMBL
P07949 RET Homo sapiens Human PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 6.7 Ki ChEMBL
P17948 FLT1 Homo sapiens Human PF07679 PF00047 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 6.7 Ki ChEMBL
P48729 CSNK1A1 Homo sapiens Human PF00069 6.7 Ki ChEMBL
P53778 MAPK12 Homo sapiens Human PF00069 6.7 Ki ChEMBL
Q13976 PRKG1 Homo sapiens Human PF00027 PF16808 PF00069 6.7 Ki ChEMBL
Q9BXA7 TSSK1B Homo sapiens Human PF00069 6.7 Ki ChEMBL
Q08881 ITK Homo sapiens Human PF00779 PF00169 PF07714 PF00017 PF00018 6.6 Ki ChEMBL
Q86V86 PIM3 Homo sapiens Human PF00069 6.6 Ki ChEMBL
Q9BZL6 PRKD2 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 6.6 Ki ChEMBL
P11362 FGFR1 Homo sapiens Human PF07679 PF00047 PF07714 6.5 Ki ChEMBL
P29597 TYK2 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 6.5 Ki ChEMBL
Q7L7X3 TAOK1 Homo sapiens Human PF00069 6.5 Ki ChEMBL
Q96GD4 AURKB Homo sapiens Human PF00069 6.5 Ki ChEMBL
Q9UM73 ALK Homo sapiens Human PF12810 PF00629 PF07714 6.5 Ki ChEMBL
P05129 PRKCG Homo sapiens Human PF00130 PF00168 PF00069 PF00433 6.4 Ki ChEMBL
Q14680 MELK Homo sapiens Human PF02149 PF00069 PF21594 6.4 Ki ChEMBL
Q8NE63 HIPK4 Homo sapiens Human PF00069 6.4 Ki ChEMBL
Q9HBY8 SGK2 Homo sapiens Human PF00069 PF00433 6.4 Ki ChEMBL
P00519 ABL1 Homo sapiens Human PF08919 PF07714 PF00017 PF00018 6.3 Ki ChEMBL
Q16620 NTRK2 Homo sapiens Human PF07679 PF13855 PF16920 PF01462 PF07714 6.3 Ki ChEMBL
O15264 MAPK13 Homo sapiens Human PF00069 6.2 Ki ChEMBL
P28482 MAPK1 Homo sapiens Human PF00069 6.2 Ki ChEMBL
Q13882 PTK6 Homo sapiens Human PF07714 PF00017 PF00018 6.2 Ki ChEMBL
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 6.0 Ki ChEMBL
Q13554 CAMK2B Homo sapiens Human PF08332 PF00069 6.0 Ki ChEMBL
Q9H3Y6 SRMS Homo sapiens Human PF07714 PF00017 6.0 Ki ChEMBL