Molecule Details
| InChIKey | XEULHZNCFYMNHT-IGCPIRJNSA-N |
|---|---|
| Compound Name | N-[(E)-[4-(1-aminoethyl)-1,3-thiazol-2-yl]methylideneamino]-6-(1-fluoro-2-methylpropan-2-yl)thieno[2,3-d]pyrimidin-4-amine |
| Canonical SMILES | CC(N)c1csc(/C=N/Nc2ncnc3sc(C(C)(C)CF)cc23)n1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 6.76 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P11802 | CDK4 | Homo sapiens | Human | PF00069 | 7.3 | IC50 | ChEMBL;BindingDB |
| P24385 | CCND1 | Homo sapiens | Human | PF02984 PF00134 | 7.3 | IC50 | ChEMBL |
| P24864 | CCNE1 | Homo sapiens | Human | PF02984 PF00134 | 6.2 | IC50 | ChEMBL |
| P24941 | CDK2 | Homo sapiens | Human | PF00069 | 6.2 | IC50 | ChEMBL;BindingDB |