1-N-[4-(6-cyanoquinazolin-4-yl)oxyphenyl]-1-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

InChIKey	`XEGPHZMYVJLNIO-UHFFFAOYSA-N`
Compound Name	1-N-[4-(6-cyanoquinazolin-4-yl)oxyphenyl]-1-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
Canonical SMILES	`N#Cc1ccc2ncnc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2c1`
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	3
Pfam Stratification	Homologous
Avg pChEMBL	6.83
Source	BindingDB

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
P08581	MET	Homo sapiens	Human	PF07714 PF01437 PF01403 PF01833	7.1	IC50	BindingDB
P30530	AXL	Homo sapiens	Human	PF00041 PF13927 PF07714	7.1	IC50	BindingDB
Q12866	MERTK	Homo sapiens	Human	PF00041 PF00047 PF13927 PF07714	6.3	IC50	BindingDB