Molecule Details
| InChIKey | XDXOWJKRCDMDIP-UHFFFAOYSA-N |
|---|---|
| Compound Name | Tert-butyl 2-[4-[4-[[1-[(4-fluorophenyl)carbamoyl]-cyclopropanecarbonyl]-amino]phenoxy]-7-methoxyquinolin-6-yl]pyrrole-1-carboxylate |
| Canonical SMILES | COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1-c1cccn1C(=O)OC(C)(C)C |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 3 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 6.93 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
Target Activities (3)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P08581 | MET | Homo sapiens | Human | PF07714 PF01437 PF01403 PF01833 | 7.3 | IC50 | ChEMBL;BindingDB |
| Q12866 | MERTK | Homo sapiens | Human | PF00041 PF00047 PF13927 PF07714 | 7.3 | IC50 | ChEMBL;BindingDB |
| P30530 | AXL | Homo sapiens | Human | PF00041 PF13927 PF07714 | 6.3 | IC50 | ChEMBL;BindingDB |