Molecule Details
| InChIKey | XBGWAKUQSRNWMA-UHFFFAOYSA-N |
|---|---|
| Compound Name | 4-[6-[4-(4-Methylpiperazin-1-yl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline |
| Canonical SMILES | CN1CCN(c2ccc(-c3cnc4c(-c5ccnc6ccccc56)cnn4c3)cc2)CC1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 6.92 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P37173 | TGFBR2 | Homo sapiens | Human | PF08917 PF07714 | 7.8 | IC50 | ChEMBL;BindingDB |
| P36897 | TGFBR1 | Homo sapiens | Human | PF01064 PF00069 PF08515 | 7.1 | IC50 | ChEMBL;BindingDB |
| P36896 | ACVR1B | Homo sapiens | Human | PF01064 PF00069 PF08515 | 6.7 | IC50 | ChEMBL;BindingDB |
| Q9Y478 | PRKAB1 | Homo sapiens | Human | PF16561 PF04739 | 6.0 | IC50 | ChEMBL;BindingDB |