Molecule Details
InChIKeyXAHJIRNRDAKTEF-UHFFFAOYSA-N
Compound NameABT-869 acid metabolite A-849529
Canonical SMILESNc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cc(C(=O)O)ccc4F)cc3)c12
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)18
Pfam Stratification Cross-Family
Avg pChEMBL6.56
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (18)
Target Gene Organism Category Pfam pChEMBL Type Source
Q9HAZ1 CLK4 Homo sapiens Human PF00069 7.6 Ki ChEMBL
O75582 RPS6KA5 Homo sapiens Human PF00069 PF00433 7.4 Ki ChEMBL
P08581 MET Homo sapiens Human PF07714 PF01437 PF01403 PF01833 7.0 Ki ChEMBL
Q13188 STK3 Homo sapiens Human PF11629 PF00069 6.9 Ki ChEMBL
O00311 CDC7 Homo sapiens Human PF00069 6.6 Ki ChEMBL
P51817 PRKX Homo sapiens Human PF00069 6.6 Ki ChEMBL
Q96GD4 AURKB Homo sapiens Human PF00069 6.6 Ki ChEMBL
Q96RG2 PASK Homo sapiens Human PF13426 PF00069 6.6 Ki ChEMBL
O00444 PLK4 Homo sapiens Human PF00069 PF18190 PF18409 6.5 Ki ChEMBL
O14965 AURKA Homo sapiens Human PF00069 6.5 Ki ChEMBL
Q12851 MAP4K2 Homo sapiens Human PF00780 PF00069 6.5 Ki ChEMBL
Q9HBY8 SGK2 Homo sapiens Human PF00069 PF00433 6.4 Ki ChEMBL
Q9Y4K4 MAP4K5 Homo sapiens Human PF00780 PF00069 6.4 Ki ChEMBL
O60674 JAK2 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 6.2 Ki ChEMBL
Q13237 PRKG2 Homo sapiens Human PF00027 PF00069 6.2 Ki ChEMBL
Q13976 PRKG1 Homo sapiens Human PF00027 PF16808 PF00069 6.1 Ki ChEMBL
P07333 CSF1R Homo sapiens Human PF00047 PF25305 PF07714 6.0 Ki ChEMBL
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 6.0 Ki ChEMBL